Sacubitril is a blood pressure medication that works by increasing the levels of certain types of protein in the body that can dilate blood vessels. This can help lower blood pressure by reducing sodium levels in the body.
Valsartan is an angiotensin II receptor blocker which works by preventing the blood vessels from narrowing, which in turn improves blood flow and lowers blood pressure.
Sacubitril and valsartan combination are two drugs used together alongside other medicines to treat chronic heart failure in adults and reduce the number of hospital visits needed for associated heart problems. This medication is only available via prescription from your doctor and is available in the dosage form of tablet for oral consumption.
Along with its intended effects, the consumption of sacubitril and valsartan can produce some unwanted side effects. Inform your doctor or a healthcare professional urgently if you suffer from any of the following side effects while taking sacubitril/valsartan.
Some side effects usually don't require urgent attention. However, if you find the side effects are impacting your everyday life, then you should get in touch with a local pharmacist or your doctor for advice and information on ways to reduce or prevent the side effects.
Remember you can report all side effects to the FDA on 1-800-FDA-1088. You may experience side effects that are not on this list. If you experience anything abnormal, contact a healthcare professional for advice.
The final dosage of any drug will depend on a variety of factors. These include your age, your height, and weight, the severity of your condition, your past medical history, current medications you are on and how to react to the first dose. This information is to be used only as a guide. Do not stop, start or change any doses without guidance from your doctor. The following information applies to the following strength(s) of sacubitril and valsartan, 24 to 26 mg; 97 to 103 mg and 49 to 51 mg.
The initial dose is 49 mg of Sacubitril combined with 51 mg of valsartan given twice a day via oral consumption. The maintenance dose is typical, 97 mg of sacubitril and 103 mg of valsartan twice a day via oral consumption.
If you miss a dose of sacubitril and valsartan, take it as soon as you remember. If it's near the time of your next scheduled dose then skip the dose you missed. Take your next dose at its scheduled time. Under no circumstances should you double doses.
Interactions can happen between drugs that cause harmful side effects. It's therefore important that you inform your doctor or a healthcare professional of all the current drugs you are taking, as well as drugs you have taken in the past. This includes prescription, non-prescription drugs, vitamins and herbal remedies. It's also important you let your doctor know of any medical conditions you suffer/have suffered from and any that run in the family history.
Using this drug with any of the following medications is not recommended. Your doctor may change some of the other medications you take or alternatively decide not to treat you with this drug at all.
The use of this drug with any of the following medications isn't usually recommended, but in some circumstances, it may be required. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this drug with any of the following medications can cause an increased risk of some side effects. However, sometimes the use of both drugs may be the best treatment. but using both drugs may be the best treatment for you. If you are prescribed both medicines your doctor may alter the dose or change how often you use the medications.
If you suffer from other medical conditions, they could interact with the effectiveness of these drugs. Ensure you inform your doctor or healthcare professional of any other health problems you suffer from, including:
Before you take this product, you should inform your pharmacist or doctor if you are allergic to either sacubitril or valsartan, or to other ARBs (such as losartan, candesartan), or to ACE inhibitors (such as ramipril, quinapril). You should also inform them if you have any other allergies including, allergies to animals, foods, dyes, preservatives etc. This drug may contain inactive ingredients which could increase your chance of having an allergic reaction or cause other problems. For more details, you should speak with your local pharmacist or doctor.
You should not take sacubitril and valsartan within a thirty-six hour period before or after you have taken any ACE inhibitors.
Studies have not taken place regarding the relationship of age to the effects of valsartan and sacubitril combination on the pediatric population. Therefore efficacy and safety have not been established.
Studies that have been performed to date have not indicated a geriatric-specific problem that could limit the useful nature of this drug combination in the older population.
Do not use this drug combination if you are pregnant. Stop using the medication immediately and inform your doctor urgently if you become pregnant whilst taking this medication. Sacubitril and valsartan can cause death or injury to an unborn baby if you take the medicine during your second or third trimester. Use an effective form of birth control to keep prevent you from falling pregnant.
Since there have been no adequate studies in women for determining infant risk when using this drug whilst breastfeeding, it is unknown if this drug passes into breast milk. You should discuss with your doctor and weigh the potential benefits and the potential risks before you begin taking this medication whilst breastfeeding.
This medication needs to be stored at 77°F (25°C); excursions permitted between 59°F and 86°F (15°C/ 30°C). This medication should also be protected from moisture, so needs to be stored in a dry place away from damp.
When used correctly, sacubitril and valsartan combination is successful in treating chronic heart failure. It's extremely important that your doctor or healthcare professional continually monitors you or your child's progress whilst taking this medication via regular visits. This is to ensure that the medication is working as it should be and to test for any unwanted side effects. These can be visited via simple urine and blood tastes taken regularly. To limit interactions, you should inform your doctor of any medication you are currently taken or if you are currently suffering from any other medical problems. This drug cannot be taken if you are pregnant and if you fall pregnant whilst taking this drug, it's vital that you inform your doctor immediately. Since it's unknown whether this drug passes into breast milk, you will have to weigh up the risks and benefits alongside your doctor and come to a decision.