Sebelipase Alfa (Intravenous)

Used to treat patients who suffer from Lysosomal acid lipase (LAL) deficiency, Sebelipase Alfa can only be administered by a trained nurse or doctor.

Overview

Sebelipase Alfa is a drug that comes in injection form and is administered to patients who are suffering from Lysosomal acid lipase (LAL) deficiency. It is a drug that is only available by prescription and you should never attempt to access it unless prescribed by a doctor.

Sebelipasa Alfa is known to react with a number of other drugs, as well as a variety of pre-existing medical conditions and foodstuffs. As such, your doctor will need to first give you a full analysis to ensure it is a suitable course of treatment for you. Below you can find further information regarding Sebelipase Alfa, such as regarding any potential side effects or warnings to look out for.

Be sure to attend all scheduled meetings with your doctor during your treatment process, as they can best advise you on any side effects that may occur, and also to track your progress. It may be that your dosage needs to be adjusted at some point, by attending those meetings, your condition can best be treated.

Conditions Treated

  • Lysosomal acid lipase (LAL) deficiency

Type of Medicine

  • Solution for injection

Side Effects

A number of different side effects can occur whilst you are undergoing a course of Sebelipase Alfa. Some of these side effects may be discomforting but won't be particularly harmful to you. However, there are some side effects which should worry you and you should look out for. If you experience any of the effects as listed directly below, then contact your doctor immediately.

More common:

  • Hyperventilation
  • Dry mouth
  • Unusual weakness or tiredness
  • Pounding in the ears
  • Reddening of the skin, most notably around the ears
  • Stomach or abdominal pain
  • Nervousness
  • Paleness of the skin
  • Swelling of the throat, face, eyes, or inside of the nose
  • Agitation or anxiety
  • Hoarseness
  • Rash, itching or hives
  • Irregular heartbeats
  • Irritability
  • Diarrhea
  • Difficulty with swallowing or breathing
  • Restlessness
  • Fever
  • Headache
  • Dizziness
  • Nausea
  • Tightness in the chest
  • Vomiting
  • Trouble sleeping
  • Shaking
  • Skin rash, encrusted, scaly, and oozing
  • Fast or slow heartbeat
  • Blurry vision
  • Chills
  • Coughing
  • Irregular or slow breathing

Less common:

  • Redness of the white part of the eyes
  • Rapid shallow breathing
  • Redness of the skin
  • Swelling of the eyelids
  • Chest discomfort
  • Puffiness or swelling of the eyelids or around the eyes, tongue, lips, and face
  • Fast, pounding, or irregular pulse or heartbeat

As mentioned, you may also experience a number of other side effects which, though uncomfortable, are not necessarily an immediate cause for concern. Nevertheless, if you experience any of the following side effects and they are worrying you at all then do contact your doctor and notify them. It may be that they can more accurately identify the cause of the problems and find a way to adjust your situation so that you no longer experience them.

  • Troubled breathing with exertion
  • Unusual bruising or bleeding
  • Muscle aches
  • Sore throat
  • Runny or stuffy nose
  • Pale skin
  • Difficulty with bowel movements (stool)
  • Sneezing

Though this list of potential side effects is extensive, it is not necessarily complete, You may encounter other side effects as a result of taking Sebelipase Alfa. If so, then make your doctor aware so they can try and prevent them from happening.

Dosage

Your exact dosage will depend upon a number of different factors and may be adjusted during your course of treatment. Sebelipasa Alfa is given intravenously and is usually administered once a week or once every other week. It is given in a medical environment by a trained nurse and the infusion process usually takes around two hours each time.

Interactions

It is very common for certain drugs to have some sort of reaction when used at the same time as other drugs. Such interactions are relatively common with Sebelipase Alfa. For this reason, it is wise to properly to consult with your doctor before beginning a course of treatment taking Sebelipase Alfa. Be sure to make them aware of any and all drugs you are taking, be them prescription, non-prescription, herbal or vitamin-based. They are best positioned to understand any sort of anticipated interactions and to adjust your dosage of any of the two drugs to offset interactions.

The same goes for other aspects of your dietary intake, including what you eat, drink and smoke. Your doctor can advise you on any specific adjustments you should make in order to minimise any sort of unwanted side effects from occurring.

You should also be honest about any pre-existing medical conditions or injuries you have. This is as well as any allergies. It may be that a course of Sebelipase Alfa will interact with your allergies or cause other medical problems to become much worse. Specifically, you should tell them if you are allergic to eggs, or any egg products, as this is known to interact with the drug.

Warnings

Some appropriate studies have been performed into the use of Sebelipase Alfa in pediatric patients. These studies have not shown any pediatric-related problems, making it safe for children one month and above. However, there are always new studies taking place, and your doctor is best placed to advise you whether it is a safe drug for your child to be administered.

As of writing, no geriatric-related problems have been documented involving the use of Sebelipase Alfa. However, it should be noted that there has not been appropriate age-related studies performed on Sebelipase Alfa. The drug may cause a reaction with existing medical conditions or those that elderly patients are more prone to, and your doctor can discuss any potential risk with you and weigh them against the benefits.

There are also no adequate studies that have been performed in determining whether or not Sebelipase Alfa is safe to be used whilst breastfeeding. Your doctor can advise you on any potential risks.

If you have ever had any sort of reaction to any drugs, or to Sebelipase Alfa, then be sure to make your doctor aware as it may not be best for you to proceed. The same goes for any other allergic reactions you have had to food, animals dyes or preservatives.

You must be sure to attend all scheduled appointments to receive your injection. Failure to attend every session could greatly reduce the effectiveness of the treatment and diminish any improvement in your health. If for some reason you are unable to attend an appointment, then make your doctor aware as early as possible so your schedule of injections can be adjusted accordingly.

You will also be required to attend regular appointments with your doctor to assess your progress over time. During these appointments, you may be required to give a blood sample so the doctor can see how your body is responding. You should attend all of these appointments as your doctor is best placed not just monitor progress, but also to spot any signs of unwanted side effects and reduce their impact.

One potential allergic reaction that can occur whilst taking Sebelipase Alfa is anaphylaxis. You should be careful to look out for any signs of this as it can be life-threatening and requires you to seek immediate medical assistance. Here are signs of anaphylaxis for you to look out for:

  • Wheezing
  • Chest discomfort
  • Fast or irregular breathing
  • Changes in facial skin colour
  • Fast or irregular heartbeat or pulse
  • Swelling of the skin similar to hives
  • Running nose
  • Itchy rash
  • Swelling or puffiness around the eyes and eyelids.

Storage

You will not be required to store Sebelipase Alfa at any time during your treatment. It can only be administered by a trained healthcare professional and done so in a hospital setting as you will need to allow the drug to slowly infuse over a two hour period. The administering nurse or doctor will be responsible for ensuring the drug is safely stored.

Summary

If you suffer from Lysosomal acid lipase (LAL) deficiency, then Sebelipase Alfa is often the most suitable course of treatment for helping improve your quality of health. Do be aware that the drug can only be prescribed by your doctor and is not available over the counter. To achieve maximum benefits from taking Sebelipase Alfa, be sure to attend all of the scheduled meetings with your doctor and also for receiving the injection. This way, your progress can be most accurately documented and any adjustments made.

As listed above, you will see that there are a number of potential interactions and side effects that can occur as a result of taking Sebelipase Alfa. If you notice any of the dangerous side effects at any time, or if you are overly worried at all, then contact your doctor immediately. They can assess your condition and adjust your treatment as necessary.

 

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Last Reviewed:
January 30, 2018
Last Updated:
April 05, 2018
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