Sodium Phosphate P32 (Intravenous Route)

Sodium Phosphate P32 helps treated a blood disease called polycythemia vera and some types of cancer. This may also be found under other brand names.

Overview

Sodium phosphate P32 belongs to a category of drugs known as radiopharmaceuticals, which are radioactive agents used to treat some diseases or study the function of body organs. It helps treat some types of cancer. The radioactive agent accumulates in the area with cancer and kills the tissue affected. Sodium phosphate P32 can also be taken for other medical conditions as instructed by your physician.

This medicine is only given by or under the supervision of a physician with specialized nuclear medicine training.

This medication is available in the form of a solution.

Before using Sodium phosphate P32, the following things should be considered:

Allergies

If you’ve ever had any allergic or abnormal reaction to this drug or any other drug, make sure to tell your doctor. Also tell them if you’ve got any other allergies, for example to animals, foods, dyes, and preservatives. For nonprescription drugs, read the ingredients on the label or package carefully.

Pediatric

Studies on Sodium phosphate P32 have only been conducted in adults, and there isn’t any specific information on its use in kids. However, kids are extremely sensitive to radiation effects. This may increase the risk of effects during as well as after treatment.

Geriatric

Older people are very sensitive to radiation effects. This may also increase the risk of effects during treatment and afterwards.

Pregnancy

Inform your doctor if you’re expecting or want to get pregnant. The FDA categorizes a drug depending on the safety of its use during pregnancy. There are five categories (A, B, C, D, X) used to classify potential risk to the fetus when a medicine is used during pregnancy. Sodium phosphate P32 is in category C.

In studies done in animals, pregnant ones were given Sodium phosphate P32 and gave birth to some babies with problems. However, there have been no well-controlled studies done in humans. Thus, this drug can be taken if the possible advantage to the mother outweighs the possible risks to the fetus.

Breastfeeding

There are not enough studies done in women to determine infant risk when taking this medicine during breastfeeding. Be sure to weigh the possible pluses against the possible negatives before taking Sodium phosphate P32 while breastfeeding.

Conditions Treated

  • Polycythemia Vera
  • Chronic myelocytic leukemia
  • Chronic lymphocytic leukemia
  • Skeletal metastases

Type of Medicine

  • Radiopharmaceutical

Side Effects

Aside from its vital effects, Sodium phosphate P32 can cause a number of adverse side effects. When it’s taken at recommended doses, Sodium phosphate P32 rarely causes side effects. But blood problems like anemia or a drop in white blood cell numbers may happen in certain patients.

In addition, these side effects can occur in people with bone cancer who are being given Sodium phosphate P32 to relieve pain.

More common:

  • Diarrhea
  • Fever
  • Vomiting
  • Nausea

Call your physician promptly if you have any of these effects:

Allergic reaction:

  • Hives or itching
  • Swelling in the face or hands
  • Tingling or swelling in the throat or mouth
  • Chest tightness
  • Unusual bleeding/bruising/weakness

If you have other effects you believe are caused by Sodium phosphate P32, inform your doctor.

You may not need to report some Sodium phosphate P32 side effects. Always consult your healthcare professional or doctor for medical advice.

Dosage

The doses of Sodium phosphate P32 will vary between patients. Usual Sodium phosphate P32 doses for adults range from 1 millicurie (37 megabecquerels) to 5 millicuries (185 megabecquerels). The dose you get depends on your age, size, and blood counts (blood test measurements).

The level of radiation your body receives to treat a medical condition is so many times higher than that of any diagnostic tests, like nuclear medicine scans and x-rays. Repeated doses might be needed, depending on the type of condition you suffer from and how you’re responding to treatment.

Your doctor will determine your dose, as well as schedule. The medication is given via a needle put in a vein.

You will receive Sodium phosphate P32 while you’re in a cancer treatment center or hospital. A healthcare specialist will administer this medicine to you.

Medicines used for cancer treatment are really strong and can cause numerous side effects. Before receiving Sodium phosphate P32, make you know all its benefits and risks. It’s essential that you work with your doctor closely during treatment.

This medicine must be administered on a predetermined schedule. Call your doctor, treatment clinic, or home health caregiver if you’ve missed a dose.

Interactions

Although certain drugs shouldn’t be taken together at all, sometimes two different drugs may be taken together even if there could be an interaction. In such cases, your physician may change your dose, or issue other precautions. Make sure to tell your healthcare specialist if you’re using any other medicines, be it prescription or nonprescription.

Other interactions:

Certain drugs shouldn’t be taken at or around meal times or when eating certain foods because interactions could occur. Interactions may also happen if you use tobacco or alcohol with certain medications. Discuss with your physician the use of Sodium phosphate P32 with food, cigarettes, or alcohol.

Warnings

Ask your healthcare specialist before taking any other drug, including prescription and nonprescription drugs, vitamins, minerals, and herbal products.

  • This medicine shouldn’t be given for intracavitary use.
  • Overdose of this medication may produce severe effects on your hemopoietic system.
  • Have your bone marrow and blood carefully examined at regular intervals.
  • Sodium phosphate usually never localizes in retinoblastomas.
  • You shouldn’t receive Sodium phosphate P32 if you’ve had allergies to it.
  • The presence of certain medical issues can affect your use of this medication. Be sure to tell your physician if you suffer from any other medical conditions.
  • Be sure to let your healthcare professional know if you’re breastfeeding or pregnant, or if you’re taking other drugs to treat cancer.
  • Your doctor will carry out regular lab tests to assess the effects of Sodium phosphate P32. Honor all your appointments.
  • Depending on Sodium phosphate P32’s reaction after you take it, for example, if you’re feeling drowsy, dizzy, or have any other weakness, don’t drive or use heavy machinery after taking this medication.
  • As prescribed by your pharmacist, it’s risky to drink alcohol while taking medications as it exposes you to drowsiness and other health risks.
  • Please check the directions on how to take Sodium phosphate P32 and ensure it isn’t a controlled substance. Consult your physician for proper guidance, recommendation, and prescription.
  • As with the use of other radioactive substances, healthcare professionals should take steps to minimize patients and occupational workers’ exposure to radiation when taking Sodium phosphate P32.
  • Radiopharmaceuticals should only be given by healthcare professionals who are trained and experienced in safely using and handling radionuclides with approval by the right government agency in charge of licensing radionuclide use.
  • No long-term studies in animals have been done to assess mutagenic potential, carcinogenic potential, or whether this medication affects male or female fertility.

Storage

  • Keep Sodium phosphate P32 at room temperature (i.e. 20-25 degrees Celsius).
  • Sodium phosphate P32’s storage and disposal should be managed in such a way that it complies with the regulations of the agency responsible for licensing its use.

Summary

Sodium phosphate P32 helps improve one’s condition by stimulating the metabolic and proliferative activity of cells.

Before you use Sodium phosphate P32, report all medications you use to your doctor, for example, over-the-counter products (e.g. minerals, vitamins, herbal supplements and so on), and prescription medications. Also report your pre-existing medical conditions, allergies, and current health status (such as upcoming surgery, pregnancy, etc.)

Some health conditions can make you more vulnerable to Sodium phosphate P32’s side effects. Take the medication as instructed by your healthcare professional or follow the directions on the product’s insert. Your dosage will depend on your medical condition. Inform your healthcare specialist if your condition gets worse or persists. Also, have your healthcare specialist regularly examine your bone marrow and blood.

  • Those who are hypersensitive to this medication should not take it. Additionally, Sodium phosphate P32 shouldn’t be taken by those who suffer from the following conditions:
  • Chronic myelocytic leukemia with the leukocyte count below 20, 000/cu mm
  • Bone metastases with the leukocyte count below 5, 000/cu mm
  • Bone metastases with the platelet count under 100, 000/cu mm
  • Polycythemia vera with the leukocyte count below 5,000/cu mm
  • Those being treated with a chemotherapy medication
  • Sodium phosphate P32 does interact with other drugs. Please consult your doctor and pharmacist for more information.
  • Sodium phosphate P32 is only given by a doctor or under his or her direct supervision. The doctor should have specialized nuclear medicine training.
  • Sodium phosphate P32 comes in the form of a solution. It can also be found under other brand names.
  • Call your healthcare specialist as soon as you experience any of these Sodium phosphate P32 side effects: unusual bruising/bleeding/weakness, itching or hives, chest tightness, difficulty breathing, tingling or swelling in your throat or mouth, or swelling in your hands or face.
Resources
Last Reviewed:
January 31, 2018
Last Updated:
February 10, 2018
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