Sumatriptan and Naproxen

Sumatriptan and naproxen is a combination drug used in the treatment of acute migraine headaches.


Sumatriptan and naproxen relieves the symptoms of acute migraine headaches and, as such, should only be used to treat a migraine attack that has already started. Sumatriptan and naproxen should not be taken for the treatment of cluster headaches, nor should it be used as a preventative medication in anticipation of future migraines.

Sumatriptan and naproxen should also be avoided in the treatment of any headaches that result in loss of movement along one side of the patient’s body.

As well as its primary effect of migraine headache relief, sumatriptan and naproxen has been shown to relieve other symptoms associated with the condition, including sensitivity to light and sound, vomiting, and nausea.

This combination drug works in two ways:

Sumatriptan belongs to the triptan class of tryptamine-based medicines, being a serotonin receptor agonist. It works by narrowing the blood vessels in and around the patient’s brain, causing a cessation from immediate pain.

Naproxen is a non-steroidal anti-inflammatory drug (or NSAID), which works by prompting a reduction of specific hormones responsible for causing pain and inflammation within the patient’s body.

Sumatriptan and naproxen, as a combination medicine, is only available with a prescription from your doctor or healthcare professional, following a detailed consultation.

Sumatriptan and naproxen is available in the following dosage forms:

  • tablet

Conditions Treated

  • acute migraine attacks
  • symptoms associated with migraine headaches (sensitivity to light and sound, vomiting, and nausea)

Type of Medicine

  • tryptamine-based serotonin receptor agonist
  • non-steroidal anti-inflammatory drug

Side Effects

As well as its anticipated and desired effects, sumatriptan and naproxen has been known to result in a number of unwanted effects. While it is by no means likely that all, or any, of these side effects, will occur, if any of them should do so, you may need to seek medical attention.

Should any of the following side effects occur during your course of treatment with sumatriptan and naproxen, be sure to speak to your doctor straight away:

  • tingling, burning, itching, prickling, numbness, pins and needles, or crawling feelings
  • chest pain or discomfort
  • pounding, irregular, racing, or fast pulse or heartbeat
  • throat, neck, or jaw pain

While the side effects listed above are likely to require the attention of a medical professional, some side effects might occur that normally would not require you to consult your doctor. Many of these may go away during your course of treatment as you find your body adjusting itself to the intake of medicine. Also, your prescribing doctor might be able to offer advice on how to reduce or prevent the impact of some or all of these effects. Should any of these effects continue throughout your course of treatment, or should any of them become bothersome, be sure to speak with your healthcare professional.

  • sudden sweating
  • discomfort, pain, or upset stomach
  • unusual drowsiness, or sleepiness
  • redness around the arms, neck, face, and upper chest
  • nausea
  • muscle tightness
  • loss or lack of strength
  • indigestion
  • heartburn
  • feeling of warmth
  • feeling hot
  • dry mouth
  • dizziness
  • belching
  • sour or acid stomach

These lists are not exhaustive, and other side effects might occur in some patients that are not listed here. Should you notice any other side effects during your course of sumatriptan and naproxen, be sure to speak to your doctor.


The dosage of sumatriptan and naproxen prescribed will differ from patient to patient. Always follows the directions from your prescribing doctor, or the instructions on the label. The information that follows demonstrates the average reported dosages of sumatriptan and naproxen. If you are prescribed a different dose to these, do not alter it unless specifically told to do so by your healthcare professional.

The amount of sumatriptan and naproxen that you take will depend on how strong this combination medicine is. The length of your course of treatment with sumatriptan and naproxen, the time you should let elapse between each dose, and the amount of dosages you should be taking each day will all depend upon the nature and severity of the medical condition for which you have been prescribed the medication.

For oral dosage tablets:

For migraine headaches:

Adults: Take one tablet, once per day. You are allowed to repeat the dosage once per day, so long as two hours have passed. You must not take more than two tablets in any given 24 hours.

Children between the ages of twelve and seventeen: one tablet to be taken once a day. You must not take more than one tablets in any give 24 hours.

Children under the age of twelve: usage and dosage must always be determined by your doctor.

Major Drug Interactions

While there are certain medicines that should never be used together because of dangerous interactions that might result between the two of them, there are other cases where using two different medications is the preferred form of treatment, even though interactions are known, or suspected, to occur. In such cases, your prescribing doctor might choose to alter your dosage, or may take other precautions to counteract any negative interactions that might occur. If you are prescribed sumatriptan and naproxen by your doctor, it is vital that you inform them if you are currently using any of the following medicines. These interactions have listed based on their potential impact, so this list may not be exhaustive.

Using sumatriptan and naproxen alongside the following medications is not advised. Your prescribing doctor might choose not to treat you with sumatriptan and naproxen after all, or they might make changes to the other medications you are taking.

  • Zolmitriptan
  • Tranylcypromine
  • Selegiline
  • Safinamide
  • Rizatriptan
  • Rasagiline
  • Procarbazine
  • Phenelzine
  • Naratriptan
  • Moclobemide
  • Methysergide
  • Methylergonovine
  • Methylene Blue
  • Linezolid
  • Ketorolac
  • Isocarboxazid
  • Iproniazid
  • Furazolidone
  • Frovatriptan
  • Ergotamine
  • Ergonovine
  • Ergoloid Mesylates
  • Eletriptan
  • Dihydroergotamine
  • Bromocriptine
  • Almotriptan

Using sumatriptan and naproxen alongside the following drugs is often not recommended, but sometimes it might be required. Should your doctor prescribe both medicines together, they might well alter the dose, or the frequency, of the drugs, in order to mitigate the impact of the interactions.

  • Ziprasidone
  • Xipamide
  • Warfarin
  • Vortioxetine
  • Vorapaxar
  • Vilazodone
  • Venlafaxine
  • Valdecoxib
  • Trolamine Salicylate
  • Trimipramine
  • Trichlormethiazide
  • Triamterene
  • Treprostinil
  • Trazodone
  • Tramadol
  • Torsemide
  • Tolmetin
  • Tolfenamic Acid
  • Tirofiban
  • Tinzaparin
  • Ticlopidine
  • Ticagrelor
  • Tiaprofenic Acid
  • Tianeptine
  • Tenoxicam
  • Tapentadol
  • Tacrolimus
  • Sulindac
  • Sulfasalazine
  • St John's Wort
  • Spironolactone
  • Sodium Salicylate
  • Sibutramine
  • Sertraline
  • Salsalate
  • Salicylic Acid
  • Salicylamide
  • Rofecoxib
  • Rivaroxaban
  • Reviparin
  • Reboxetine
  • Protriptyline
  • Protein C
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Probenecid
  • Prednisone
  • Prednisolone
  • Prasugrel
  • Pralatrexate
  • Polythiazide
  • Pixantrone
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Phenyl Salicylate
  • Phenprocoumon
  • Phenindione
  • Pentoxifylline
  • Pentosan Polysulfate Sodium
  • Pemetrexed
  • Paroxetine
  • Parnaparin
  • Parecoxib
  • Paramethasone
  • Palonosetron
  • Oxyphenbutazone
  • Oxycodone
  • Oxaprozin
  • Opipramol
  • Olsalazine
  • Nortriptyline
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Nefazodone
  • Naproxen
  • Nadroparin
  • Nabumetone
  • Morniflumate
  • Mirtazapine
  • Milnacipran
  • Metolazone
  • Methylprednisolone
  • Methyclothiazide
  • Methotrexate
  • Mesalamine
  • Meperidine
  • Meloxicam
  • Melitracen
  • Mefenamic Acid
  • Meclofenamate
  • Meadowsweet
  • Magnesium Salicylate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Lorcaserin
  • Lofepramine
  • Lithium
  • Levomilnacipran
  • Lepirudin
  • Ketoprofen
  • Indomethacin
  • Indapamide
  • Imipramine
  • Iloprost
  • Ibuprofen
  • Hydroflumethiazide
  • Hydrocortisone
  • Hydrochlorothiazide
  • Heparin
  • Granisetron
  • Gossypol
  • Ginkgo
  • Furosemide
  • Fondaparinux
  • Fluvoxamine
  • Flurbiprofen
  • Fluoxetine
  • Fluocortolone
  • Flufenamic Acid
  • Floctafenine
  • Feverfew
  • Feprazone
  • Fepradinol
  • Fentanyl
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethacrynic Acid
  • Escitalopram
  • Eptifibatide
  • Epoprostenol
  • Eplerenone
  • Enoxaparin
  • Edoxaban
  • Duloxetine
  • Droxicam
  • Doxepin
  • Dothiepin
  • Dolasetron
  • Dipyrone
  • Dipyridamole
  • Digoxin
  • Diflunisal
  • Diclofenac
  • Dibenzepin
  • Diazoxide
  • Dexketoprofen
  • Dexibuprofen
  • Dexfenfluramine
  • Dexamethasone
  • Desvenlafaxine
  • Desirudin
  • Desipramine
  • Deflazacort
  • Dasabuvir
  • Danaparoid
  • Dalteparin
  • Dabigatran Etexilate
  • Cyclosporine
  • Cyclopenthiazide
  • Cortisone
  • Clopidogrel
  • Clopamide
  • Clonixin
  • Clomipramine
  • Citalopram
  • Cilostazol
  • Choline Salicylate
  • Choline Magnesium Trisalicylate
  • Chlorthalidone
  • Chlorothiazide
  • Certoparin
  • Ceritinib
  • Celecoxib
  • Cangrelor
  • Buprenorphine
  • Bumetanide
  • Bufexamac
  • Budesonide
  • Bromfenac
  • Bivalirudin
  • Bismuth Subsalicylate
  • Betamethasone
  • Beta Glucan
  • Benzthiazide
  • Bendroflumethiazide
  • Bemiparin
  • Balsalazide
  • Aspirin
  • Argatroban
  • Ardeparin
  • Apixaban
  • Anagrelide
  • Amtolmetin Guacil
  • Amoxapine
  • Amitriptylinoxide
  • Amitriptyline
  • Amineptine
  • Amiloride
  • Acenocoumarol
  • Acemetacin
  • Aceclofenac
  • Abciximab

Using this sumatriptan and naproxen with the following medication might result in an higher chance of certain side effects. However, utilising both drugs concurrently could be the best way to treat your condition. Should your prescribing doctor choose to use both drugs at the same time, they might decide to amend the dosage or the frequency of one or other of the medications.

  • Zofenopril
  • Valsartan
  • Trandolapril
  • Timolol
  • Temocapril
  • Telmisartan
  • Spirapril
  • Sotalol
  • Ramipril
  • Quinapril
  • Propranolol
  • Practolol
  • Pindolol
  • Perindopril
  • Pentopril
  • Penbutolol
  • Oxprenolol
  • Olmesartan
  • Nebivolol
  • Nadolol
  • Moexipril
  • Metoprolol
  • Metipranolol
  • Losartan
  • Lisinopril
  • Levobunolol
  • Labetalol
  • Irbesartan
  • Imidapril
  • Fosinopril
  • Esmolol
  • Eprosartan
  • Enalaprilat
  • Enalapril
  • Delapril
  • Cilazapril
  • Celiprolol
  • Carvedilol
  • Carteolol
  • Captopril
  • Candesartan
  • Bisoprolol
  • Betaxolol
  • Benazepril
  • Azilsartan Medoxomil
  • Azilsartan
  • Atenolol
  • Alacepril
  • Acebutolol

Certain drugs should not be taken at the same time as eating food (or, in some cases, certain types of food) as they run the risk of interactions taking place. Similarly, the use of tobacco and alcohol at the same time as taking your medication has been shown to cause unwanted interactions in some cases.

Using this sumatriptan and naproxen with the following is normally not recommended and should be avoided wherever possible. If utilised together, your prescribing doctor might choose to alter the dosage, or amend the frequency of your doses.

  • Tobacco


Whenever you decide to use medication, you must always weigh the potential risks of doing so against the good it will do. You and your prescribing doctor will make this decision between you, following a suitable consultation. When considering the use of sumatriptan and naproxen for migraine relief, you should consider the following:

Inform your doctor if you have had an allergic or otherwise unusual reaction to sumatriptan and naproxen in the past, or to any other kind of medication. Also advise them if you suffer from any other allergies, including an allergic reaction to animals, dyes, foods, or preservatives.

Appropriate studies have yet to be performed regarding the effects of sumatriptan and naproxen in children under the age of twelve years.

Sumatriptan and naproxen is not recommended amongst those elderly patients how suffer from hypertension, blood vessel disease, heart disease, or kidney problems.

Studies among pregnant women have shown positive evidence of fetal abnormalities occurring. As such sumatriptan and naproxen should not be used by women who are, or who are expecting to become, pregnant. In such circumstances, the risk outweighs the potential benefit of taking the drug.

There have been no adequate studies undertaken in women to determine the risk to nursing infants when using sumatriptan and naproxen during breastfeeding. Patients should weight the potential risk of doing so against the possible benefits of continuing with the course of medication.

Use sumatriptan and naproxen as instructed by your prescribing doctor. Do not take a greater amount, or take it more frequently, or take it for a longer period of time than your doctor recommends. Taking too much of this drug may increase the risk of side effects.

Do not use sumatriptan and naproxen to ease the pain from regular headaches. You should ask your doctor about what you can do to relieve a normal headache.

Be sure to swallow the sumatriptan and naproxen tablet whole. You should not break, chew, or crush the tablet on ingestion. You may take the tablet with food, or without.

Certain other medical conditions can have an impact on the effective use of sumatriptan and naproxen. Be sure to inform your doctor of any other medical conditions you suffer from, but particularly the following:

Using sumatriptan and naproxen may make the following conditions worse:

  • history of bowel or stomach ulcers, or bleeding
  • history of seizures
  • kidney disease
  • history of inflammatory bowel disease, uncluding ulcerative colitis, or Crohn Disease
  • controlled hypertension, or high blood pressure
  • edema, or fluid retention
  • congestive heart failure
  • bleeding problems
  • anemia

Sumatriptan and naproxen should not be used if you suffer from any of these conditions:

  • history of transient ischemic attack
  • history of stroke
  • peripheral vascular disease
  • severe liver disease
  • ischemic bowel disease
  • uncontrolled hypertension (or, high blood pressure)
  • hemiplegic migraine (that is, a migraine that induces paralysis)
  • heart surgery, including any coronary artery bypass graft (or, CABG)
  • problems with heart rhythm, including Wolff-Parkinson-White syndrome and arrhythmia
  • blood vessel or heart problems
  • history of heart attack
  • basilar migraine
  • aspirin-sensitive asthma
  • history of aspirin sensitivity
  • angina (chest pain)

The chances of side effects from sumatriptan and naproxen presenting themselves may be increased if you suffer from the following:

  • Raynaud syndrome
  • hypercholesterolemia (high levels of blood cholesterol)
  • diabetes
  • history of coronary artery disease

You should have regular check ups with your doctor throughout your treatment, so that they may check your progress. It will enable them to confirm that the sumatriptan and naproxen is having the desired effect, and whether you should carry on using it. Your prescribing doctor will likely wish to take urine and blood tests to ensure there are no unwanted effects.

Consult your doctor if you do not get good relief from using sumatriptan and naproxen, or if your headaches become worse, or occur with a greater frequency than they did prior to starting your course of treatment.

If you are pregnant, be sure to let your doctor know. Sumatriptan and naproxen is not recommended for use amongst women in the latter stages of pregnancy, unless specifically advised by the prescribing doctor.

You should not take sumatriptan and naproxen if you have taken an MAO inhibitor in the last fortnight.

You should not take sumatriptan and naproxen if you have used another migraine treatment in the last twenty-four hours.

Sumatriptan and naproxen may cause unwanted issues should you currently suffer from heart disease. If your prescribing doctor thinks there may be a health risk, they might choose to have you take the first dose of the drug in their office or clinic.

Sumatriptan and naproxen may increase the chance of developing a blood clot, stroke, or heart attack, particularly if you have a history of heart disease, diabetes, hypertension, high levels of cholesterol, if you are a smoker, a male over the age of forty, or if you are a female who has gone through the menopause. Using sumatriptan and naproxen for an extended period of time can also exacerbate the risk

If you exhibit discomfort in the chest, or tightness to the neck or jaw after taking sumatriptan and naproxen, be sure to contact your doctor. Also speak to your doctor should you develop severe or sudden stomach or abdominal pain after taking this drug.

Sumatriptan and naproxen may cause ulcers or bleeding in your intestines or stomach. This effect can happen without any warning signs, and is more likely to occur if you have a history of stomach ulcers, if your are currently in poor health, if you drink alcohol or smoke regularly, if you are over the age of sixty, or if you are currently using certain other medications, such as an anti-coagulant or a steroid.

Do not use sumatriptan and naproxen if you have already been prescribed other medication that includes naproxen. Using such drugs concurrently can lead to serious unwanted effects.

Sumatriptan and naproxen can cause a very serious condition known as serotonin syndrome, if taken alongside certain medications. This especially includes anti-depressant medication, so be sure to inform you prescribing doctor if you are currently on any other drugs before taking this.

Sumatriptan and naproxen can cause a serious allergic reaction known as anaphylaxis. It is a rare, but dangerous, reaction and is more likely to occur if you are allergic to aspirin, or to any non-steroidal anti-inflammatory drugs (otherwise known as NSAIDs). Developing fast, irregular breathing, fainting spells, or sudden gasping for air upon taking sumatriptan and naproxen may be a sign of anaphylaxis, as you should seek immediate medical attention.

Serious skin reactions have also been reported with sumatriptan and naproxen. You should consult your health care professional immediately should you exhibit any of the following during your course of treatment with the drug:

  • unusual weakness or tiredness
  • ulcers, white spots, or sores on the lips, or in the mouth
  • sore throat
  • red lesions on the skin
  • muscle or joint pain
  • itching
  • fever
  • diarrhea
  • cough
  • chills
  • loose, peeling, or blistering skin

If you exhibit any symptoms of liver problems during your course of treatment with sumatriptan and naproxen be sure to consult with your prescribing doctor. This can yellowing of the eyes or skin, pain to the upper stomach, a loss of appetite, nausea, pale stools, and dark urine.

If you find yourself rapidly gaining weight, suffering from shortness of breath, pains or discomfort in the chest, extreme weakness or tiredness, irregular heartbeat or breathing, or an excessive swelling to the feet, hands, ankles, or wrists whilst on your course of treatment with sumatriptan and naproxen, consult your GP immediately. These could be an indication of you body retaining excess amounts of water, or a possible heart condition.

Using too much sumatriptan and naproxen may actually make your headaches worse, as your body acclimatises to the medication. You should talk to your prescribing doctor if this risk concerns you. It is also useful to keep a migraine diary, noting down the frequency and the potency of your migraines, as well as what medication you take to alleviate the pain.

Should you suffer a change in your vision during your course of treatment with sumatriptan and naproxen, you should inform your prescribing doctor straight away, as you may need to be examined by an ophthalmologist. This can include double-vision, blurred vision, and difficulty with reading.

Consumption of alcohol can cause headaches, or make existing headaches worse. If you suffer from acute migraine attacks, including painful headaches, you are advised to avoid alcoholic beverages, wherever possible.

Sumatriptan and naproxen has been known to make some people drowsy, dizzy, or less alert than usual. Should any of these side effects happen to you during your course of treatment, make sure you do not use machinery, drive, or perform any other activity that may be dangerous whilst less alert.

If you are due to undergo any medical examinations or tests, be sure to inform the doctor in charge that you are on a course of sumatriptan and naproxen. Some tests have reported seeing their results affected by this medication.

Do not take any other medication alongside sumatriptan and naproxen, unless you have discussed them with your prescribing doctor. This includes other prescription medication, as well as over-the-counter preparations, and herbal or vitamin supplements.


Sumatriptan and naproxen should always be stored in at room temperature, in a closed container. Be sure to keep your medicine away from direct light, moisture, and heat, and ensure that you keep it from freezing.

Sumatriptan and naproxen should always be kept beyond the reach of children.

You should never keep hold of sumatriptan and naproxen tablets that you no longer need, or which have become outdated. Should you require advice on how to get rid of any unused medication, be sure to ask your doctor.

Ask your healthcare professional how you should dispose of any medicine you do not use.


Sumatriptan and naproxen is a combination medication used in the treatment of acute migraine attacks. It has two points of impact – the blood vessels of the brain, which are narrowed by the sumatriptan, triggering a cessation of pain from the migraine itself; and hormones in the body that provoke pain and inflammation, which are reduced by the naproxen.

Sumatriptan and naproxen is specific to providing relief from migraine headaches that are already in effect, and should not be used to prevent future attacks, nor for other kinds of headaches.

Last Reviewed:
December 24, 2017
Last Updated:
December 22, 2017