Sweet Vernal/Orchard/Perennial Rye/Timothy/Kentucky Blue Grass Mixed Pollen Allergen Extract

Mixed Pollen Allergen Extract with Timothy, Kentucky Blue Grass, Sweet Vernal, Perennial, Orchard and Rye extracts is also known under the marketing


What is Timothy, Kentucky Blue Grass, Sweet Vernal, Perennial, Orchard and Rye Mixed Pollen Allergen Extract?

Mixed pollen allergen extract is a prescription medication that is taken in tablet form, to be dissolved under the tongue. Also known as the marketing name Oralair, it has been shown to reduce symptoms found in patients suffering from grass allergies. Thanks to the use of this extract, allergy sufferers have been known to be able to reduce their use of other allergy drugs.

Mixed pollen allergen extract is an immunotherapy drug treatment. Typically, immunotherapy allergen treatments are given as a shot in the arm to patients who have tested positive for certain allergic reactions. In this case, taking mixed pollen allergen extract is far more convenient, as it is taken as a tablet under the tongue that takes 1 minute to dissolve and requires to office visit.

Approved for adults and children aged 10 to 65, this medication has been proven effective in patients who have tested positive for grass allergens through use of a skin or blood test by their physician.

How does Timothy, Kentucky Blue Grass, Sweet Vernal, Perennial, Orchard and Rye Mixed Pollen Allergen Extract work?

This medication works by conditioning the body’s immune system to be less sensitive to grass pollens in order to lessen the severity of allergy symptoms. The extract treatment begins at least 4 months before the beginning of grass pollen allergy season. By conditioning the body to accept grass allergens in low formulations, the medication has thereby prepared the immunity defenses to lessen their reaction when exposed to these allergens in the air.

Conditions Treated

  • Mixed pollen allergies

Type of Medicine

  • Immunological Agent/Immunotherapy

Side Effects

As this medication is an extract of grass pollens such as timothy, Kentucky blue grass, sweet vernal, perennial, orchard and rye, introduction of these pollens into a patient who has tested positive for allergies could cause the patient to have an allergic reaction to the drug itself. Should these side effects occur, contact your physician right away:

  • Chest congestion
  • Difficulty breathing
  • Cough
  • Fever
  • Itchy ears, tongue or mouth
  • Breathing noisily
  • Soreness in the throat
  • Swollen mouth
  • Glands that are swollen
  • Tight chest
  • Body aches
  • Headache
  • Chills
  • Hives, welts, itching, skin rash
  • Hoarse or lost voice
  • Tingling, numbness around mouth
  • Red skin
  • Sweating
  • Sneezing, nose running
  • Fatigue, weakness
  • Difficulty with swallowing
  • Dizziness, lightheadedness
  • Fast, irregular heartbeat
  • Swelling that resembles hives in the facial area, the limbs or on the torso and sex organs
  • Puffy, swollen eyelids, facial features, tongue or lips
  • Red face, arms, neck, or upper chest
  • Tender, swollen lymph glands

The following side effects are less common, but should they occur and be determined to be severe or prolonged in nature, contact you health care provider right away:

  • Sour stomach
  • Gas and bloating
  • Stomach discomfort
  • Burning in chest or abdomen
  • Vomiting
  • Nausea
  • Diarrhea
  • Dry mouth
  • Dry eyes

Occasionally side effects occur that aren’t severe or potentially dangerous. Side effects such as these are temporary and usually go away after your body becomes accustomed to the drug. If you feel that the side effects you are experiencing are severe or prolonged in duration, check with your physician for their recommendation on how to eliminate or ease these side effects.


Do not increase the dose or frequency or prolong the use of this medication and take only as your health care provider has prescribed for you. To do so is to risk unwanted side effects that may cause severe health issues.

Read and follow all provided patient information include with your prescription packaging. Any questions you have should be directed to your doctor or pharmacist.

Begin your immunotherapy treatment with this extract medication at least four months before the expected start of the earliest grass pollen season. Continue your dosage daily throughout the season, completing your doses when the last grass pollen is finished for the year. Your first dose should be taken in a formal health care setting to monitor you just in case of a reaction to this extract. If your first dose goes well and you have tolerated the medication with minimal side effects, the remainder of your treatment will be on your own.

Your doctor will prescribe a dose of this medication specifically for you, taking into account your overall health, age, symptoms and other data. The following is representative of an average dose of this immunotherapy medication; your dose may vary.

In adults who are age 18 to 65, one tablet in the size of 300 Index of Reactivity or IR units, is to be taken once per day. Children 10 to 17 years will take a smaller 100 IR for their first dose, followed by two 100 IR tablets on day two, and up to 300 IR once per day on if they have tolerated the drug well. Take the tablet as follows:

  • Wash hands
  • Remove tablet from blister pack
  • Place tablet under the tongue immediately
  • Allow tablet to dissolve for 1 minute; do not swallow
  • Do not drink anything until 5 minutes post dose

Children should be supervised when taking this drug to prevent them from drinking liquids or swallowing saliva before the drug has a chance to dissolve.


Allergic reactions you have experienced in the past with extract medications such as this or any other drugs should be disclosed to your health care provider before beginning this immunotherapy.

Safety and effectiveness data on the use of this immunotherapy extract treatment in children who are under 10 years of age has not been determined and therefore it is not recommended for this age group. By the same token, there is no data available from studies taken on the use of immunotherapy mixed pollen allergen extract treatment on patients who are older than 65 years of age. This age group should only be prescribed allergen immunotherapy on the advice of their health care provider.

Women who are pregnant or who are of childbearing age should use caution before taking immunotherapy allergy treatment, as no risk information is available to determine the safety of this drug. Similarly, breastfeeding women have not been observed in order to determine risk to their infants while on this medication. The potential of this drug to benefit pregnant or breastfeeding women along with any potential side effects to their fetus or infants should be discussed in detail with health care professionals who are familiar with their particular health situation.

Other medications, when used with mixed pollen allergen extract, may cause unintended interactions that are potentially harmful. It is of critical importance that your disclose your full medical history as well as details of any drugs you are currently taking or have taken in the recent past before you begin to use immunotherapy allergen medication or any other drug. Include all prescription as well as non-prescription medications you may be taking and details of any vitamin, holistic or herbal supplements or treatments.

Treatment with mixed pollen allergen extract and the use of alcoholic beverages, illegal drugs or tobacco should be discussed with your physician so that you are aware of any risk interactions.

These medical problems are known to affect the effectiveness and/or increase the risks associated with the treatment of mixed pollen allergen extract. Make sure your doctor is aware of any conditions you have prior to treatment with this drug. These conditions include:

  • Mannitol allergies including allergic reactions to croscarmellose sodium, microcrystalline cellulose, magnesium stearate, colloidal anhydrous silica, or lactose monohydrate
  • Asthma
  • Eosinophilic esophagitis
  • Sublingual allergen immunotherapy allergic reactions
  • Angina
  • Arrhythmia
  • Lung problems such as COPD
  • Heart attack
  • Hypertension
  • Dental extractions
  • Mouth ulcerations such as the condition known as Thrush
  • Oral surgery

Use of this drug with the following medical conditions may worsen their symptoms or make the condition itself worse:

  • Systemic allergies


Regular check-ups by your doctor while being treated with an immunotherapy regimen such as mixed pollen allergy extract will be required. Your doctor will examine you to determine how effective this treatment has been for you and help you decide on whether or not to continue using it.

Mixed pollen allergen extract immunotherapy may cause allergic reactions of a serious nature which could include anaphylaxis, which requires immediate medical attention. If you have the following symptoms of anaphylaxis, contact emergency medical services and your physician at once:

  • Panting or irregular breathing
  • Gasping or wheezing
  • Fainting
  • Changes to color of the face
  • Fast, pounding heartbeat
  • Swelling to the skin in a hive-like manner
  • Puffy, swollen eyelids or around the eyes

An injection treatment may be prescribed to you that should be made available during emergencies while taking mixed pollen allergen extract. Make sure you know the signs and symptoms that require its use and that you read all information supplied with this injection. If you have any questions on how to give an injection to yourself or to your child, check with your health care provider or pharmacist. It is of critical importance that this injection be available to you or to your child if needed in an emergency. Arrange for the safe storage and transport as well as the availability of this treatment at all times, if required.

Oral surgery sites including tooth extractions or other surgical intervention in the mouth should be allowed to completely heal before taking mixed pollen allergen extract treatment.

Unless your doctor prescribes it, this medication should not be taken with other drugs including any other prescription, non-prescription, herbal, holistic or vitamin therapy.

If you miss a dose of mixed pollen allergen extract, contact your health care provider or your pharmacist for instructions on how to get back on the treatment program.


Store your tablets of mixed pollen allergen extract in their original packaging at room temperature and away from sources of heat, light or moisture. Do not allow this medication to freeze. Keep this and other drugs out of sight and reach of children and pets.

Should you have expired doses of mixed pollen allergen extract that you don’t use, check with your doctor or pharmacist on the safest way to dispose of this medication.


Timothy, Kentucky blue grass, sweet vernal, perennial, orchard and rye mixed pollen allergen extract is a doctor prescribed medical treatment known as immunotherapy, that works by introducing a known allergen into a patient in low doses, allowing the body’s own immunity to adjust to the presence of the irritant, thereby lessening the symptoms of the allergy during full-blown grass pollen seasons.

This medication is prescribed in tablet form for adults and children 10 to 65 years of age that is to be taken under the tongue and allowed to dissolve for one minute, waiting at least five minutes before eating or drinking. Dosage varies depending on age of the patient, severity of the allergy symptoms and other factors but is typically a once daily 300 IR tablet. Use of this immunotherapy treatment in pregnant or breastfeeding women is under doctor’s recommendation only. It is not recommended that this drug be prescribed for children who are under 10 years of age or adults over 65 as these age groups have not been studied with regard to risk factors or effectiveness concerns that are age related.

Side effects can include a severe allergic reaction to the drug known as anaphylaxis, which is why the first dose is typically taken in a clinical setting. Thereafter, dosing can be taken at home but an emergency injection will most likely be prescribed in case of severe allergic reaction. Swelling in the face area accompanied by trouble breathing are two signs of severe allergic reaction to this drug and should be reported to your physician immediately.

Patients who have undergone or who must undergo oral surgical procedures or extractions of teeth should not take this drug until these sites have healed completely. Consult with your doctor if you are scheduled for any oral surgical procedures while under this immunotherapy treatment.

Those with breathing problems including asthma or high blood pressure are advised to use caution when on this medication. Inform your health care provider of any medical conditions as well as any prescription, non-prescription or other drug therapies you are taking.

Store this medication out of sight and reach of children and away from heat, light and moisture. Dispose of unused or expired medication in a safe manner as instructed by your health care provider or pharmacist.

Last Reviewed:
December 24, 2017
Last Updated:
February 10, 2018
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