Taliglucerase Alfa (Intravenous)

Taliglucerase Alfa is administered intravenously to improve spleen, liver, bone, and blood problems resulting from Gaucher disease, but doesn't cure the genetic condition and treatment is required for life.


Taliglucerase Alfa is in a class of medicines known as enzyme replacement therapies. It's specifically a substitute for glucocerebrosidase, an enzyme that naturally occurs in the body and helps break down certain kinds of fatty substances.

Taliglucerase Alfa helps to treat Gaucher disease in adults and children. Adults normally suffer from type 1 of the disease while kids suffer from type 1 and 3 of the disease. A rare genetic problem, Gaucher disease occurs when the protein used for breaking down some cell waste products is not as effective as it should be or it's not present.

Taliglucerase Alfa replaces this enzyme, enabling the body to recycle the wastes properly.

Taliglucerase Alfa can be found under several brand names or in various forms, including Elelyso. Any particular brand name of Taliglucerase Alfa may not be found in all the forms or prescribed for all the problems discussed below. In addition, some forms of Taliglucerase Alfa may not be taken for all the problems discussed below.

Your physician may have recommended Taliglucerase Alfa for problems other than the ones listed below. If you and your physician haven't discussed this or you aren't sure why you're using this medicine, talk to your physician. Don't stop taking Taliglucerase Alfa without talking to your doctor.

Don't give Taliglucerase Alfa to anybody else, no matter if their symptoms are similar to yours. It can be dangerous for anyone to take Taliglucerase Alfa if their physician hasn't prescribed it.

Conditions treated

Type of medicine

  • Enzyme

Side effects

Aside from its useful effects, Taliglucerase Alfa can bring about some adverse effects. While not everyone experiences these side effects, if you notice any of them you may need immediate medical attention.

Check with your nurse or doctor promptly if you experience any of these effects while using Taliglucerase Alfa.

More common:

  • Dizziness
  • Feeling of warmth
  • Nausea or vomiting
  • Chest tightness
  • Irritation of the throat
  • Hives or welts, skin rash, or itching
  • Huge, hive-like swelling on the eyelids, face, lips, throat, tongue, legs, feet, hands, or sex organs
  • Redness of skin
  • Redness of neck, face, arms, and less often, upper chest
  • Less common:
  • Confusion
  • Blurred vision
  • Fast heartbeat
  • Sweating
  • Cough
  • Difficulty with swallowing
  • Unusual tiredness/weakness
  • Lightheadedness/faintness/dizziness when suddenly getting to your feet
  • Swelling/puffiness around the eyes or on the eyelids, lips, face, or tongue

Some Taliglucerase Alfa side effects that normally don't need treatment may occur. The side effects may disappear as you adjust to the drug during treatment. Moreover, your healthcare giver can suggest ways to alleviate or prevent some of them. See your healthcare giver promptly if have questions about these side effects, if they persist, or if they trouble you.

More common:

  • Headache
  • Feeling of warmth
  • Joint pain
  • Muscle stiffness/pain
  • Difficulty with moving
  • Abdominal/stomach pain
  • Frequency unknown:
  • Blistering
  • Bleeding
  • Burning
  • Discoloration of skin
  • Feeling of pressure
  • Itching
  • Hives
  • Infection
  • Inflammation
  • Numbness
  • Itching
  • Lumps
  • Rash
  • Pain
  • Scarring
  • Redness
  • Soreness
  • Swelling
  • Tenderness
  • Stinging
  • Ulceration
  • Tingling
  • Warmth at injection site


The right Taliglucerase Alfa dose varies from one person to another and depends on body weight, depending on how much is required to be effective and how well it's tolerated.

Taliglucerase Alfa is given into a vein (intravenous infusion) over 1-2 hours, every 14 days.

This medication must be handled carefully, and it's usually given in a clinical or hospital setting and sterile equipment is required for preparation. Under certain circumstances, you might be shown how to prepare and give yourself this medicine at home.

Many things may affect the dosage of medicine one needs; for example, body weight, other medications, and other medical conditions. If your physician has recommended a different dose to the ones discussed here, don't change how you're taking the medicine without first consulting your doctor.

It is vital that you administer Taliglucerase Alfa exactly as instructed by your healthcare provider. If you miss one appointment to get this medication, make sure to contact your physician right away to rearrange your appointment.

If somebody has overdosed on Taliglucerase Alfa and has severe symptoms such as troubled breathing or passing out, call 911. Alternatively, you can contact a poison control agency promptly. If you're in the US, you can call your local poison control service at 1-800-222-1222. If you're in Canada, you can call your provincial poison control agency.


Inform your healthcare giver about all sorts of medicines you're taking, including non-prescription, prescription, and herbal medicines. Also report any nutritional supplements you're using. As street drugs, alcohol, cigarettes, and caffeine can affect how medications work, you should let your healthcare giver know if you take them. Based on your specific situation, your doctor might tell you to:

  • Stop using one of the drugs
  • Change from one of the drugs to another
  • Change your way of using one or both drugs
  • Not change anything

An interaction between medicines doesn't always mean you stop using one of them. Discuss with your physician how any medication interactions should be controlled or how they are being controlled.

Drugs can interact with some foods. Sometimes this can be harmful to you and your physician may advise that you avoid some foods. When it comes to Taliglucerase Alfa, there aren't any specific foods you must avoid when receiving this medicine.


Before you get started with any medication, make sure to report to your doctor any allergies or medical problems you may have, whether you're breastfeeding or pregnant, any drugs you're taking, as well as any other essential details about your health. The following factors can affect how this medication should be used.

Allergic reactions - certain people may develop serious allergies after using Taliglucerase Alfa. These allergies may happen up to a day after receiving a Taliglucerase Alfa dose. Here are some signs of a severe allergic reaction: hives, severe rash, swollen throat/face, or troubled breathing. Get medical attention immediately if any of these symptoms occur.

Dizziness - Taliglucerase Alfa may cause dizziness. So, don't operate machinery, drive a car, or carry out other risky tasks until you find out how this drug affects you.

Infusion-related reactions - just like other enzyme replacement therapies, Taliglucerase Alfa may cause serious infusion-related reactions; for example, serious allergic reactions. Your physician will monitor you closely during and after infusion and can give you other drugs before you receive Taliglucerase Alfa to ward off these reactions.

If you suffer symptoms of a reaction to the infusion, such as chills, fever, troubled breathing, tightness of throat or chest, rash, and stomach upset, let your healthcare professional know immediately. Symptoms can often be alleviated by temporarily discontinuing the medicine or slowing down intake, as well as taking other medicines to treat the symptoms.

It's vital to take the medicine(s) recommended by your physician before Taliglucerase Alfa is administered to you. If you suffer a very serious infusion reaction, get additional medications from your doctor to treat the problem. Ask your physician for more information.

Pregnancy - Taliglucerase Alfa shouldn't be taken during pregnancy unless its benefits far outweigh the risks. Make sure to contact your physician immediately if you get pregnant while using Taliglucerase Alfa.

Breastfeeding - it's not yet known whether this medication is released into human milk. If you're using this medication and are breastfeeding, it may harm your little one. Discuss with your physician whether it's advisable to continue breastfeeding while using Taliglucerase Alfa.

Children - the efficacy and safety of Taliglucerase Alfa use in children hasn't been determined for kids under the age of 2.


Before mixing, keep the medicine's bottle in the refrigerator.

Protect Taliglucerase Alfa from freezing and light.

Once mixed, check the product's directions and ask your pharmacist about storage information.

Dispose of any unused medication.

Keep all drugs far away from little ones and pets.

Don't flush drugs in wastewater i.e. down the drain or toilet unless told to do so.

When this product expires or you no longer need it, discard it properly.

Consult your local garbage disposal firm or pharmacist about how to safely discard medications.


It's vital to honor all your appointments for receiving Taliglucerase Alfa. If you miss one appointment, contact your healthcare giver immediately to rearrange another appointment.

Taliglucerase Alfa comes in some variety under the Elelyso brand name.

Follow your physician's directions about any limits on activity, food, or drinks.

Some people who receive Taliglucerase Alfa have a reaction as soon as the medication is injected or about three hours later. Let your healthcare givers know immediately if you suffer a sudden headache, warmth or tingling, dizziness, chest pain, nausea, wheezing, or red skin rash.

Your physician may give you other medicines to prevent some Taliglucerase side effects.

Taliglucerase Alfa is normally administered every two weeks. Make sure to follow your physician's dosing directions carefully.

Your doctor may change your dose in some cases to ensure you receive the best possible results.

Last Reviewed:
December 23, 2017
Last Updated:
April 26, 2018
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