Technetium Tc 99m Mertiatide (Injection)

Technetium Tc 99m mertiatide is a radioactive agent that is used in conjunction with a special type of scan to predominantly find and diagnose problems in the kidneys, urine output, and bladder.


Known as a radiopharmaceutical, technetium Tc 99m mertiatide can be used for both diagnostic and therapeutic intentions. Radiopharmaceuticals are made up of a radioisotope that is bonded to an organic molecule. This organic molecule then moves the radioisotope to specific organs, cells and tissue and can be tracked through the use of special scans.

Technetium Tc 99m mertiatide takes the form of powder. The powder has to then be mixed and then injected into the body where it will distribute in organs such as the kidneys or bladder. This radioactive substance can then be photographed and recorded from outside the body using specific cameras that will conduct a scan. This is a less invasive procedure for diagnosing organ diseases or damage and can give doctors an accurate image of how well your organs are working. Because this medicine does include treatment with radioactive materials, your doctor will ensure that the benefits that it can offer far outweigh the risks.

Technetium Tc 99m mertiatide must only ever be mixed by and administered under the immediate supervision of a doctor who has had specialized training in nuclear medicine. It will also only ever be administered in a hospital.

Conditions treated

  • Diagnosis of kidney problems
  • Diagnosis of urine output problems
  • Diagnosis of bladder problems

Type of medicine

  • Radiopharmaceutical

Side effects

As with all medicines, technetium Tc 99m mertiatide does have the potential to cause side effects in some patients. You may find that some of these side effects may disappear once your body has become adjusted to the medication, or that they are less bothersome to your routine. These types of side effects may not need medical attention, but if you are concerned, it is always best to alert your doctor.

If you experience hives, swelling of the eyelids, itching, nausea, headaches or vomiting, then this could be a sign of an allergic reaction. An allergic reaction to Technetium Tc 99m Mertiatide is usually noticeable within a short timeframe from its administration and it is likely that medical professionals will be able to treat it. Always make sure to be as transparent as possible with your healthcare team though. Allergic reactions to technetium Tc 99m mertiatide are a more rare occurrence, with it affecting 1 to 10 per 10,000 users.

Very rare and serious side effects include difficulty breathing, a high temperature, nervousness, seizures, pounding in the ears, shaking chills, erratic heartbeat or a tight feeling in the chest. In the event that you experience any of the reactions, it is important that you let your doctor know right away.


The technetium Tc 99m mertiatide dosage is always in the form of a kit. It will always be administered and prepared in a hospital or medical environment, so will only be given to you by qualified people who have been trained to handle radioactive material with safety. The amount of technetium Tc 99m mertiatide used in your dose will be decided by your doctor. Your doctor will always try to give you the lowest dose possible, as long as it can produce sufficient X-ray images. In the majority of cases, you will only need one injection and this will provide an adequate amount for your scans. When deciding on the right dosage, your doctor will take into account any previous illnesses, health problems, your age and the type of treatment that you will be having before they determine an amount.

For most adults and the elderly, the standard dose of technetium Tc 99m mertiatide is 37-185 MBq, injected into a vein. When measuring radioactivity, MBq is the unit used. It also defines the activity of a mass of radioactive material.

For teenagers and children under 18 years old, a lower dose is recommended according to the patient's body surface area.

Before your treatment, it is advised that you drink and urinate as much as possible. This should also be continued in the six hours once your treatment has finished, as it will prevent the active substance from gathering in your bladder. Prior to your treatment, your doctor will discuss how to manage any after effects of this medicine as well as give you the opportunity to ask any questions you may have.


When tested, this medication was not known to influence or be influenced by other medicines commonly used; however, it is important that your doctor is made aware of any prescription or nonprescription medications that you may be taking in advance to your treatment. This should also include any herbal and over-the-counter treatments. Even though some medicines should never be used in combination with each other, in certain cases, different medicines must be used together. With the right information, your doctor will be able to make an informed decision and ensure that your treatment is as effective as it can be.

In addition to this, dietary and lifestyle factors should be considered and discussed with your doctor before starting your treatment. Alcohol can exacerbate certain side effects, as can smoking tobacco or eating certain sugars and salts. It is important to discuss the effects that food, alcohol and tobacco may have with technetium Tc 99m mertiatide before your treatment begins.


Discussing any prior allergies and sensitivities to a medication is hugely important before starting your treatment. Your doctor should be aware of anything that may have caused a reaction in the past.

Technetium Tc 99m mertiatide has not been shown to cause adverse reactions in children and the elderly and poses the most risk to infants and fetuses. Animal studies have revealed that there is an adverse effect on fetuses in all trimesters, placing this medication in the pregnancy category C. This means that no risks have been ruled out, but that the potential benefits may outweigh the risks of using of this drug in pregnant women. If you are pregnant or become pregnant in the run-up to your treatment, it is essential that you inform your doctor.

Breastfeeding has been found to have harmful effects on children. It is not recommended that you breastfeed whilst receiving this treatment, and if you plan on breastfeeding following it, you must discuss the effects with your doctor as well as how long you can wait until you continue breastfeeding. Tell your doctor if you are breastfeeding as he may delay treatment until breastfeeding is finished. Your doctor may ask you to stop breastfeeding for 8 or more hours following your treatment, as well as dispose of any milk made during or following your exposure to Technetium Tc 99m mertiatide. If it is not possible to discontinue breastfeeding, an alternative medication should be prescribed.

To make sure that your treatment is as effective as possible, your doctor will want to maintain close observation whilst the medication is being administered and in your system.


It is unlikely that you will come into contact with the Technetium Tc 99m mertiatide kit, due to it having to be handled and administered by trained professionals. As with all medication, it must be disposed of if it has passed its label expiry date. It must also be kept at a storage temperature of 2-8°C.

This medication must be kept in a sterile, medical environment and can only be handled by healthcare professionals.


Technetium Tc 99m mertiatide is a diagnostic treatment that poses no real disruption to a patient's routine. It is an accurate way of discovering illnesses or damage to the kidneys, bladder or urinary tract and acts as a quick, effective agent that may be the beginning of long-term treatment for some.

The only demographic who are more likely to experience a negative impact from Technetium Tc 99m mertiatide are pregnant women and breastfeeding mothers. For both, this treatment can be harmful to infants, but not the mother. For this reason, if you are pregnant, breastfeeding or expecting, it is hugely important that you discuss your options with your doctor. They may decide that this treatment is not the best course of action, or they may decide that the benefits outweigh the risks.

To ensure that your treatment goes as smoothly as possible, it is important to drink plenty of water and urinate often. As well as doing this before your treatment, you must do it in the six hours following it, to help your body get rid of the radioactive substance. By doing this, you will also stop it from creating any potential lasting effects. However, this is a very unlikely scenario.

If you have any questions or would like to know how you can manage your treatment in the best possible way, make sure to discuss it with your doctor.

Last Reviewed:
December 24, 2017
Last Updated:
April 05, 2018
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