Technetium Tc 99m Pentetate

Technetium Tc 99m pentetate is a radiopharmaceutical treatment that is injected into the body and then seen through a special type of scan.

Overview

Technetium Tc 99m pentetate injection is a radioactive agent. Also known as a radiopharmaceutical, it is predominantly used for diagnostic purposes. Technetium Tc 99m pentetate is also used to help control, prevent, treat and improve diseases including renal perfusion (the volume of blood flow delivered to the kidneys) and estimating glomerular filtration rate (testing how well the kidneys are working).

Technetium Tc 99m pentetate is administered by intravenous route (injection). Once it has been injected into the body, it will distribute itself in specific organs and help highlight any problematic areas. The radioactive substance will then be recorded by your medical team by being photographed with specific cameras that will perform a scan. It forms an invasive and relatively quick procedure that can help accurately diagnose organ diseases or damage. However, due to the fact that Technetium Tc 99m pentetate means being treated with radioactivity, your doctor will ensure that its potential benefits outweigh its risks.

This medicine can also be used by healthcare professionals to see a detailed image of the brain and its structure. This agent is also known by its brand names An-DTPA and MPI DTPA and must only be used by a qualified nuclear-medicine specialist.

This medication will only be administered in a hospital setting under the supervision of trained professionals.

Conditions treated

  • Technetium Tc 99m pentetate is used to diagnose problems in the kidneys and brain.

Type of medicine

  • Radiopharmaceutical diagnostic agent.

Side effects

Technetium Tc 99m pentetate has the potential to cause side effects in some patients, although severe side effects are very rare. You may discover that some of these side effects are only noticeable whilst your body adjusts to the medication, or that they don’t cause you much concern. These types of side effects can go without medical attention, but if you are in any way worried about them, please alert your healthcare professional.

Some reactions indicate that a patient is having an allergic reaction. This is serious and must be treated right away. Alert your doctor immediately if you experience difficulty in swallowing, wheezing, swelling of the face, itching, nausea, headaches or a rash. Allergic reactions often become apparent during or shortly after the administration of medicine, so hospital staff will be able to treat this.

Adverse reactions that include bleeding, blistering, discoloration of the skin, a feeling of pressure, numbness, pain, scarring, soreness, stinging, ulceration, or heat at the injection site are all signs of rare and serious reactions that must be brought to the attention of a doctor immediately.

Some side effects that can be experienced may not be listed, so if you do notice any worrying reactions following or during your treatment, discuss them with a doctor or nurse as soon as you can.

Dosage

This medication dosage is in the form of a kit. Technetium Tc 99m pentetate should only ever be handled in a hospital setting or medical environment, and will only be administered to a patient by qualified professionals who have been trained in safely handling radioactive medicines. Your dose will be decided by your doctor who will always try to give you the lowest dose that can produce adequate X-ray images. When deciding on your dose, factors such as any prior illnesses, health problems and your age will all be taken into account. In most cases, you will only need one injection of Technetium Tc 99m pentetate for your scans.

It is advised that you urinate as soon as you can after your scan, as well as regularly in the four to six hours following it. This will stop the active substance from collecting in your bladder and causing any potential harm. Prior to your treatment, your doctor will discuss how to manage any after effects of this medicine, as well as the recommend amount that you should drink before and after. If you have any questions that you’d like to discuss, please raise them with your doctor.

Interactions

Before beginning your treatment, it is important that your doctor knows of any non-prescription or prescription medications that you may be taking in advance. This should also include any herbal treatments and vitamins. In many cases, certain medicines should never be used in combination with each other, however, in some cases, different medicines must be used together. With total transparency and information, your doctor will be able to make the correct decision and make sure that your treatment is as effective as it can be.

Alongside any medication that you may be taking, dietary and lifestyle factors should be discussed with your doctor before starting your treatment. Alcohol, tobacco and certain sugars and salts can all worsen certain side effects, as well as impact treatment. It is important to discuss the effects that food, drinking and smoking may have with this medicine and its procedure before your treatment begins.

Warnings

You must make sure that your doctor is aware of any medical problems before you begin your treatment. It is particularly important to let them know if you have kidney disease, as Technetium Tc 99m pentetate may cause negative effects. It is also essential that you discuss any allergies or sensitivities to medications that you may have experienced in the past.

Because this medication is a radioactive agent, you may have questions or concerns regarding the procedure and its effects. Make sure to voice any worries that you have with your healthcare professional before your treatment begins. Your doctor will also want to maintain close observation during your procedure, as well as after. Make sure to attend all your appointments.

If you will be pregnant or breastfeeding at the time of the procedure, it is important that you discuss it with your doctor. Technetium Tc 99m pentetate can be harmful to fetuses and infants, and it is advised that you do not breastfeed in the hours following your procedure. If you plan on breastfeeding following your treatment, your doctor may ask you to stop breastfeeding for 8 or more hours following it, as well as throw away any milk made during or following your exposure to the medication. If it is not possible to stop breastfeeding, a different medication should be prescribed.

Technetium Tc 99m pentetate is not recommended for those with hypersensitivity. If you do have this, your doctor may suggest an alternate medication.

Storage

Due to technetium Tc 99m pentetate needing to be handled and administered by nuclear-medicine trained professionals, it is highly unlikely that you will come into contact with it.

The medication will need to be disposed of if it is older than its label expiry date. It must also be kept in a sterile, hospital environment at a storage temperature of 2-8 °C.

Summary

Technetium Tc 99m pentetate has the potential to help treat, control and diagnose health problems and disease by providing doctors with an accurate picture of specific organs. Alongside this, it can also be used to learn more about organs such as the kidneys or brain. Successful treatment can result in quick diagnoses and the beginning of long-term treatment for some.

It is a quick procedure that causes a minimum amount of disruption to a patient’s routine, requiring the patient to maintain a good level of communication with the doctor and practise their pre and post treatment advice to determine the best possible results. You will be advised to drink plenty of water before and after your treatment so that you will urinate often and help your body get rid of the radioactive substance.

Technetium Tc 99m pentetate has a low risk of side effects and problems for the majority of patients. However, this treatment can be harmful to infants and fetuses. For this reason, if you are pregnant or breastfeeding, it is hugely important that you discuss it with your doctor. They may decide that this treatment is not the best course of action, or that the benefits outweigh the risks and it is possible to go ahead.

Even though this is a fast treatment that can offer quick results, it is important to remember that it is a radioactive agent. If you have any questions or would like to know more about this treatment, make sure to discuss it with your doctor.

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Last Reviewed:
December 22, 2017
Last Updated:
December 22, 2017
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