Technetium Tc 99m Succimer (Intravenous)

Technetium Tc 99m Succimer is used in patients to allow images of the kidneys to be seen so that problems can be diagnosed.


The Technetium Tc 99m Succimer is a part of the medicine group of radiopharmaceuticals. It is a radioactive material that can be used in radiotherapy for the imaging of organs to study the function and identify disease in the patient. The injection of Technetium Tc 99m Succimer is used for the imaging of the patient's kidneys for the diagnosis of kidney conditions and the analysis of kidney function.

This medicine should only be administered by a doctor or in the presence of a doctor who has specialized training in the use and handling of nuclear medicine.

Use of this medicine involves the injection of radioactive substances into your body. If you have concerns about this then you should consult with your doctor.

Pregnant women and breastfeeding mothers should consider the risks of exposing a fetus or infant to this treatment. You should discuss the use of this medication with your doctor if you are pregnant or breastfeeding. Your doctor may consider an alternative method in some cases.

Technetium Tc 99m Succimer has a short lifespan within the body and will quickly become concentrated in the kidneys. It will eventually be excreted through urine.

Condition treated

  • Kidney disease identification

Type of medicine

  • Radiopharmaceutical

Side Effects

Radiopharmaceutical medications can cause unwanted side effects in the body. While Technetium Tc 99m Succimer has very few side effects, it is important to look out for them. Although patients may not experience all or any of the following side effects, if they are experienced then the patient may be in need of medical attention.

If you experience any of the following side effects then you should inform your doctor immediately.

Occurring only rarely in patients

Other side effects will not require medical attention in most cases. If you do experience any of the following then you may wish to inform your healthcare professional of the occurrence. In some cases they may be able to help you to alleviate the symptoms of the treatment and reduce the side effects. If these side effects become bothersome or are ongoing then you should inform your doctor and seek advice.

Occurring only rarely in patients

  • Nausea or feeling of sickness
  • Rashes that may appear with flat lesions or raised lesions on the skin.

Other side effects not listed here can occur. In the case that you experience other side effects you should inform your healthcare professional right away.


This medication is injected intravenously by a doctor in a hospital environment. The dosage should be determined in relation to the weight of the patient and should be administered in a diluted form.

The dose should be given 1 to 2 hours before imaging to allow it to circulate around the body and begin to collect in the kidneys.


Medications can interact with one another in the body. In mild cases one may stop the other from working, but in serious cases they can interact with each other violently and make the side effects of the other worse. It is vitally important that you discuss all medication that you are taking with your doctor before you undergo treatment with Technetium Tc 99m Succimer. This includes all prescribed medicines, over the counter medicines, vitamin supplements and herbal remedies; all of which may interact with the medication.

You should also inform your doctor of any medical conditions that you have or have had in the past. This includes a history of alcoholism or drug abuse. Certain conditions can affect the use of this medication and certain conditions can be worsened by the use of it. Ensure that you inform your doctor of all conditions that you have before treatment is administered.


When making the decision to use this medication the benefits of doing so should be weighed against the potential risks. When considering the use of Technetium Tc 99m Succimer you should discuss and consider the following factors with your doctor:

Allergies - If you have reacted in any way violently to medication in the past then you need to share this information with your doctor. Allergies to medicines can put you at serious risk. It is especially important to share this information if you have had a reaction to radiopharmaceutical medications or other medications using radiation in the past. Allergies to foods, dyes, animals, preservatives and other substances are also important to consider.

Pediatric - The safety and efficiency of use in children have not been determined with this medication.

Geriatric - While there is not anticipated to be any complications to using Technetium Tc 99m Succimer in the elderly, it is important to consider the general health of the individual. There are more likely to be age-related complications that may affect the use of Technetium Tc 99m Succimer in elderly patients.

Pregnancy - It is known that radioactive materials can be harmful to the development of a fetus. If you are pregnant then you must inform your doctor and alternative treatments may be considered. While there have not been adequate studies on the use of this medication in pregnant females, it should be avoided where it is possible to do so. This treatment should only be used in pregnant women when there is a clear need to do so.

Breastfeeding - Radioactive materials may alter the composition of the milk in the breast and may be passed on to the infant through the milk. If you are breastfeeding a child then you should wait until the material is clear of your system before breastfeeding and the child should be monitored for side effects and adequate milk intake. It may be necessary to prepare some milk for the child for the period in which you are unable to feed them. You should also avoid contact with infants until the material has cleared from the body as the radiation can pass out through your skin.

Consumption habits - Foods, drinks, tobacco, alcohol and other substances that you are taking can affect the medication and can interact with it. Discuss your habits with your doctor before taking this medication.

When using Technetium Tc 99m Succimer it is very important that your doctor keeps monitoring you whilst it is in your system. Administration must only take place in a hospital in the presence of a doctor who is trained in the use of nuclear medicine.

Allergic reactions can occur when taking this medication. If you show signs of allergic reaction then you should inform your doctor immediately. These signs can include:

  • Itching
  • Hives
  • Swelling of the face or area around the face
  • Swelling of the hands
  • Swelling or tingling feeling inside the mouth, on the tongue or in the throat.
  • Tightness of the chest
  • Difficulty in breathing.


The kit for Technetium Tc 99m Succimer administration will be supplied in 5 vials. The kit should be stored at between 2 and 8 °C at all times, including during transport.

Protect the kit from direct light.

Once prepared the dose should be administered between 10 minutes and 4 hours after reconstitution.


Technetium Tc 99m Succimer is a radiopharmaceutical used for radiotherapy imaging of the kidneys. The use of this medication will allow doctors to examine the kidneys for disease and to assess function. This particular radiopharmaceutical will collect in the kidneys over a short period of time and is eventually all excreted through urine.

Technetium Tc 99m Succimer is a radioactive agent and will be injected into the body intravenously. If you have any concerns about this use of radioactive materials then you should discuss these concerns with your doctor.

Technetium Tc 99m Succimer should only be administered to a pregnant woman if it is clearly needed. While it is not known if this specific treatment can cause harm to a fetus, it is known that radioactive materials can be harmful to a fetus. Use of this medication on a pregnant woman should be avoided where it is possible to do so.

Breastfeeding should also be avoided during the period that this medication is active in the body. It has been shown to alter the composition of breast milk and it is known that radioactive materials can be passed on through the milk. A breastfeeding infant should be monitored for any side effects of the consumption of radioactive materials.

The lifespan of Technetium Tc 99m Succimer in the body is short and the radioactive will be collected in the kidneys at a fast rate.

Last Reviewed:
December 24, 2017
Last Updated:
April 05, 2018
Content Source: