Tedizolid (Intravenous)

Sold under the US brand name of Sivextro, tedizolid is given via injection to treat bacterial skin problems and skin structure conditions.

Overview

Tedizolid injection is used to treat skin structure and bacterial skin problems. It belongs to the family of medicines called antibiotics and it works by preventing the growth of bacteria and killing bacteria. It is only to be given under the supervision of your doctor or given directly by them only and is available in a 'powder for solution' dosage form.

Condition(s) treated?

  • Bacterial skin problems
  • Skin structure problems

Type of medicine?

  • Intravenous injection via power for solution

Side Effects

As with all medicines, there can be some unwanted side effects that aren't related to the illness you are treating. If you find you have side effects, it's important to report them to your doctor or physician. Alternatively, you can contact the FDA on 1-800-FDA-1088. Side effects associated with taking tedizolid are listed below in terms of less common or rare and more severe.

Less common or rare

Check with your doctor immediately if any of the following side effects occur while taking tedizolid:

Less common or rare

  • Stomach or abdominal tenderness
  • Blistering, bleeding, burning, infection, discoloration of the skin, itching, lumps, pain, redness, numbness, soreness, swelling, stinging, tenderness, ulceration, tingling or warmth around the injection site
  • Back pain
  • Blurred vision
  • Chills
  • Dizziness
  • Chest tightness
  • Fever
  • Headache
  • Pounding, fast or irregular pulse or heartbeat
  • Welts or hives, skin rash or itching
  • Stiffness, joint pain or swelling
  • Hoarseness
  • Vomiting or nausea
  • Pale skin
  • Pounding in the ears
  • Nervousness
  • Redness of the skin
  • Severe stomach cramps or abdominal pain
  • Swelling of the face, eyelids, hands, lips or feet
  • Fast or slow heartbeat
  • Trouble swallowing or breathing
  • Tightness in the chest
  • Unusual bruising or bleeding
  • Troubled breathing with exertion
  • Unusual weakness or tiredness
  • Severe or watery diarrhea, which could also be bloody

Severe

Most side effects that occur usually don't need medical attention and they may disappear as your body adjusts to the medicine during treatment. Also, if any side effects are bothering you or impacting your day-to-day life, you should contact your doctor or health care professional for ideas about the best ways to reduce or prevent some of these side effects listed below. Check with your doctor/physician if any of the side effects listed continue or if you have any queries or questions about them.

Less common

  • Burning, numbness, tingling, or painful sensations
  • Diarrhea
  • Unsteadiness or awkwardness
  • Weakness in the arms, hands, legs, or feet

Less common or rare

  • Blurred vision
  • Change in vision
  • Crawling, burning, itching, prickling, numbness, "pins and needles", or other tingling feelings
  • Redness of the neck, face, arms, and occasionally, the upper body chest
  • Feeling of warmth
  • Seeing floating spots before the eyes
  • Difficulty sleeping
  • Sore tongue or mouth
  • White patches on the tongue or in the mouth

Dosage

Dosage requirements of tedizolid will differ depending on individual cases. The final dosage will depend on a variety of factors such as weight, height and age. As a guide, for the use of the treatment in bacterial infections, 200 mg IV infusion of tedizolid is issued once daily for 6 days and is usually given over an hour period. If the IV line is used to administer other drugs, you need to ensure that you flush the IV with 0.9% Sodium Chloride before and after each administration of tedizolid.

Missed dose

If you miss a dose of tedizolid, take the dose as soon as you remember up to eight hours prior to the next scheduled dose. If less than eight hours remain before the next dose, wait until the next scheduled dose.

If you believe you have overdosed on this medication, then contact your nearest doctor, hospital or physician immediately. Don't assume that you will be okay.

Interactions

A total of eighteen drugs are known to interact with the use of tedizolid. It's important that you inform your doctor or physician of absolutely everything you are taking, regardless of whether it's considered herbal or not. This is not only to keep you safe but to ensure that the medication works in the way it is required in order to help assist recovery.

Major reaction

The use of Cholera is known to have a major reaction with tedizolid so should not be taken in conjunction with one another. An alternative drug needs to be taken. The cholera vaccine should not be administered to patients who have received parenteral (or oral) antibiotics within fourteen days prior to vaccination.

List of other drugs that interact with tedizolid

Inform your health professional if you are taking the following drugs. The co-administration of these with tedizolid should be avoided and alternatives offered.

  • Almotriptan
  • Citalopram
  • Amoxapine
  • Amphetamine
  • Eletriptan
  • Amitriptyline
  • Cholera vaccine
  • Bupropion
  • Dextroamphetamine
  • Clomipramine
  • Cyclobenzaprine
  • Doxepin
  • Cesipramine
  • Cesvenlafaxine
  • Dolasetron
  • Duloxetine
  • Escitalopram
  • Fluoxetine
  • Fentanyl
  • Granisetron
  • Fluvoxamine
  • Frovatriptan
  • Isocarboxazid
  • Imipramine
  • Levomilnacipran
  • Metformin
  • Lisdexamfetamine
  • Methylene blue
  • Meperidine
  • Methamphetamine
  • Naratriptan
  • Mirtazapine
  • Nortriptyline
  • Nefazodone

Warnings

As with all medications, there are particular warnings put in place to safeguard you against any problems or issues. Take careful note of the below warnings before taking tedizolid.

  • Inform your doctor if you have had previous symptoms of the flu or cold, fever or a sore throat
  • The use of tedizolid can cause diarrhea, and in some cases, it can be severe. It can also occur up to 2 months after you stop using this tedizolid. If you do experience diarrhea that continues to worsen then check with your doctor or health professional about the best option to take. Don't take any medicine to treat diarrhea without consulting with your doctor first.
  • Tedizolid has not been approved for the use by anyone under the age of 18 years old
  • It's not known whether this medicine will harm an unborn baby, so it is therefore advised only to take tedizolid if the benefits outweigh the risks. It's important to inform your doctor if you are pregnant or plan to become pregnant in the near future.
  • It has been found that tedizolid can pass into the breast milk whilst feeding and can potentially harm a nursing baby. Inform your doctor if you are breast-feeding a baby.
  • The presence of other diseases can affect the ability of tedizolid such as Colitis and Neutropenia - it is essential you inform your doctor if you are suffering from any of these.

Administration at home

Tedizolid injection is administered into a vein via the use of an IV. In certain circumstances, you may be shown how to use an IV at home. Under no circumstances should you give yourself this medicine if you don't understand how to use the injection correctly and dispose of IV tubing, needles and other equipment used. Tedizolid injection is a powder-based medicine and must be mixed with a liquid diluent in an IV bag before you can safely use it. Gently swirl but don't shake the mixed medicine as this could cause it to foam. Don't use if the medicine has changed color or it appears to have particles in it. If this happens, you should contact your nearest pharmacist for a new medication.

After mixing the tedizolid injection, it can be stored for up to 24 hours in a refrigerator or at room temperature. Each single-use bottle of injection is for use only once and should be thrown away after one use, even if some medicines remain after injecting your required dose.

Only ever use a syringe and disposable needle once. Follow any local or state laws about disposing of used syringes and needles. A trip to your local pharmacists should allow you to obtain the correct information and equipment to both store correctly and dispose of these materials.

Always use tedizolid for the full prescribed length of time. Even if your symptoms have improved, this doesn't mean the infection has completely cleared, so it's important to finish a full course. Skipping doses can increase your risk of further infection that is resistant to antibiotics. Never share this medication with anyone else.

Storage

Tedizolid medicine needs to be stored at room temperature away from heat and moisture. Prepare your tedizolid injection dose only when you are ready to give an injection.

Summary

When used correctly, tedizolid can successfully treat bacterial skin problems such as MRSA. It can be administered in a hospital or at home with the necessary instructions and with minor side effects. It is, however, important to inform your doctor or physician with a full background of your health including any medication you are on, regardless of what it is, and any previous history of illness that runs in the family. Failure to inform your doctor could result in the medication causing potential detriment to your health, or being unable to help assist in recovery from skin bacterial problems.

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Last Reviewed:
December 23, 2017
Last Updated:
April 03, 2018
Content Source: