Telavancin (Intravenous)

Telavancin is an injection used separately or in combination with other medications to treat severe bacterial infections of the skin and ventilator-assisted and hospital-acquired bacterial pneumonia (VABP/HABP).

Overview

Telavancin is an injection used alone or in combination with other medications to treat serious bacterial skin infections, and hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP). This medication is known as an antibiotic and it works by exterminating existing bacteria and preventing the growth of new bacteria. This medication should not be used to treat the common the flu, the common cold, or other viral infections.

In addition to treating bacterial skin infections, telavancin is also used to treat other related conditions. Talking to your doctor about any medications you're taking before starting telavancin is recommended. Telavancin can help patients suffering from intense skin rashes or itching and help them return to the normal routine of their daily lives. This medication may also be known by its brand name, Vibativ.

Condition(s) Treated

  • Bacterial skin infections
  • Hospital-acquired bacterial pneumonia
  • Ventilator-associated bacterial pneumonia

Type of Medicine

  • Antibiotic

Side Effects

Intravenous telavancin could potentially cause certain unwelcome side effects. You may not experience all or any of the side effects listed here, but if you do, seeking medical attention is recommended. Call your physician or other healthcare professional right away if you experience any of the following less common side effects:

  • Blood in urine
  • Difference in the amount of urine or frequency of urination
  • Difficulty breathing
  • Drowsiness
  • Nausea or vomiting
  • Increased thirst
  • Edema of lower legs or feet
  • Weakness
  • Loss of appetite

Side effects of which the incidence is unknown include:

  • Stomach or abdominal tenderness
  • Fever or chills
  • Cough
  • Difficulty swallowing
  • Lightheadedness, dizziness, or faintness, especially while standing up quickly from a sitting or lying position
  • Increased heartbeat
  • Itching of the skin or hives
  • Soreness, pain, or redness at the site of injection
  • Swelling or puffiness of the eyelids or near the lips, face, eyes, or tongue
  • Nausea or vomiting
  • Redness or rash on the face, back, bottom of the neck, arms, and upper body
  • Severe stomach or abdominal pain and cramps
  • Chest tightness
  • Uncommon weakness or tiredness
  • Severe and watery diarrhea that may contain blood

Some of these side effects do not require medical attention. This is because they might disappear on their own during treatment while your body is adjusting to the medication. Your doctor might be willing to help you find ways to reduce or prevent some of these side effects. Talk to your doctor if you experience any of these side effects, or if they become bothersome or last too long. Some of the more common side effects of this nature include:

  • Diarrhea
  • Unpleasant, bad, or unusual (after) taste
  • Foamy urine
  • Change in how you taste

Less common side effects of this nature include:

  • Shivering
  • Decreased appetite
  • Feeling unusually cold
  • Red, dry, irritated, or hot skin

This is not a complete list of potential side effects. Certain side effects that are not listed here may appear only in certain patients. If you experience side effects of this nature, contact your doctor immediately. You can report any unusual side effects you experience to the FDA (Food and Drug Administration).

Dosage

Intravenous telavancin is usually given by a trained healthcare professional or nurse. It's typically given through a needle inserted into your veins. Telavancin comes with a Medication Guide that patients should read and follow carefully. If you have any additional questions after reading it, talk to your doctor.

Your doctor may teach you how to utilize this medication. Do not miss any doses of this medication. If you happen to miss a dose accidentally, contact your doctor to find out what to do. If the solution has particles, or is leaking or cloudy, do not take it. Also do not take it if the solution changes color.

Dispose of any needles in a needle/sharp disposal box. Never reuse needles or other medical supplies. Once the box is full, follow your local regulations for properly disposing of it. Talk to your physician or pharmacist if you have any remaining questions.

This medication must be mixed with a liquid (diluent) before use. If you're using the injections at home, make sure you fully understand how to mix and store the medication.

Telavancin is typically given once every 24 hours for 7 to 21 days. Do not use this medication longer than recommended by your healthcare provider or the instructions on the label.

Mixed telavancin should be used within 4 hours if it's kept at room temperature. Each single-use vial (bottle) of telavancin is for one-time use only. Throw it away after each use, even if there's still some medication left in it after you inject yourself with your usual dosage amount.

Only use the (disposable) needle and syringe once. Consider using a puncture-proof "sharps" disposal container. Your pharmacist can tell you where you can get one and how you should properly dispose of it. Store this medicine container out of sight and reach of children, as well as family pets.

In case of accidental overdose, contact a poison control center right away or seek emergency medical attention. Be prepared to answer questions such as what was taken, how much, and when it was taken.

Interactions

Certain medications should not be used simultaneously because of a risk of a drug interaction. However, in some cases it may be necessary for treatment for a doctor to prescribe you both medications at the same time. In this case, the doctor might change the dosage on one or both of the medications, or take other necessary precautions. While taking telavancin, it's important to let your doctor know if you're taking any of the following medications, as interactions have been reported in patients using telavancin in combination with the medications listed below. This isn't an all-inclusive list, but some of the medications of this nature include:

  • Amifampridine
  • Amisulpride
  • Bepridil
  • Cisapride
  • Dronedarone
  • Heparin
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using telavancin with the following medications is typically not recommended, but might be required in special cases. If both medications are prescribed at the same time, your doctor may adjust your dosage of one or both medications. Medications of this nature include:

  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Buserelin
  • Chlorpromazine
  • Cholera Vaccine, Live
  • Cirprofloxacin
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Droperidol
  • Efavirenz
  • Erythromycin
  • Escitalopram
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroxychloronique
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Lopinavir
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Metronidazole
  • Mifepristone
  • Moxifloxacin
  • Nafarelin
  • Nilotinib
  • Nofloxacin
  • Nortriptyline
  • Octreotide
  • Ondansetron
  • Paliperidone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Perflutren Lipid Microsphere
  • Pimavanserin
  • Pitolisant
  • Posaconazole
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Salmeterol
  • Sevoflurane
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Telithromycin
  • Tetrabenazine
  • Toremifene
  • Trufluoperazine
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vemurafenib
  • Vinflunine
  • Voriconazole
  • Zuclopenthixol

Certain medical conditions can also interfere with the way telavancin works. Some of these conditions include kidney disease, congestive heart failure, diabetes, hypertension (high blood pressure), and hearth rhythm problems or a family history of heart rhythm problems. Telavancin may make some of these conditions worse or the effects of the medication may be increased because of a slower removal of the medicine from the body in patients with kidney disease. Patients with high blood pressure have an increased risk of kidney problems.

Warnings

Before taking this medication, you and your doctor must determine whether this medication is right for you and whether the good it will do is worth the potential risks. Consider the following before taking telavancin.

Talk to your doctor about any allergies you might have to any medications. Also talk to your doctor about any allergies to things such as foods, animals, dyes, or preservatives. Read the ingredients on the label of any product you talk while on telavancin. This medication can cause anaphylaxis, which can be fatal and requires immediate medical attention. Talk to your doctor if you experience trouble swallowing, itching, rashes, trouble breathing, or edema (swelling) of the face, hands, or mouth after the injection.

Call your doctor immediately if you see blood in your urine, edema (swelling) of the lower legs or feet, loss of appetite, difference in the amount of urine or the frequency of urination, drowsiness, difficulty breathing, increased thirst, or nausea or vomiting. These symptoms could be a sign of a serious kidney problem.

Telavancin can cause severe diarrhea and it can occur for up to 2 months after you stop taking it. Rather than taking medicine to treat your diarrhea, check with your doctor first, as some medications for diarrhea may make it worse or cause it to last longer. If you have any further questions about this topic, or if your mild diarrhea lasts too long or gets worse, talk to your doctor.

Telavancin may not be suitable for elderly patients, as they're more likely to experience age-related kidney problems. In this case, elderly patients should exercise caution and an adjustment may be made in their dosage of telavancin.

Be sure to let your doctor monitor your progress while taking telavancin to make sure it's working properly. Your doctor may perform blood and urine tests to check for undesirable effects.

Do not take telavancin if you're pregnant or if you're planning on becoming pregnant, as it can cause harm to your unborn baby. To prevent pregnancy while taking this medication, use an effective form of birth control. If you happen to become pregnant, or if you miss a period while taking telavancin, contact your doctor right away. In order to take telavancin, you must have a negative pregnancy test.

Do not take this medication if you're currently receiving unfractionated heparin sodium injection. Using both medications simultaneously can result in dangerous effects.

Call your doctor immediately if you experience any changes in heart rhythm. In this case, you might feel dizzy or faint, or you might have an uneven, pounding, or fast heartbeat. Let your doctor know if you or anyone in your family has or has ever had a heart rhythm problem such as QT prolongation.

Telavancin can cause a serious but rare type of infusion reaction called the "Red-man Syndrome." Contact your doctor right away if you begin experiencing chills or fever, itching, hives, nausea or vomiting, or rash or redness of the face, upper body, back, base of the neck, and arms.

Talk to the doctor treating you before you have any medical tests while taking telavancin. In some cases, the results of certain medical tests can be affected by this medication. Do not take any other medications without first discussing it with your primary doctor, including prescription and nonprescription (over-the-counter) medications, vitamins, herbal supplements, or similar products. Do not share your medication with anyone and do not take anyone else's medication.

Storage

Intravenous telavancin should be stored in the refrigerator between 35 to 46 degrees Fahrenheit (2-8 degrees Celsius). Avoid exposing this medication to excessive heat. Reconstituted solution should be stored at room temperature and used within 24 hours. When stored in the refrigerator, telavancin should be used within 72 hours.

Make sure to keep all medications out of sight and reach of children and pets, as well as other people.

Summary

While telavancin is a greatly beneficial drug, it can pose a serious risk to patients who fail to report other medications or allergies to their doctors. As a treatment designed to treat serious bacterial skin infections, telavancin works by killing existing bacteria and preventing the growth of new bacteria. An antibacterial drug, telavancin is given by injection either alone or in combination with other medications. People with certain medical conditions have an increased risk of side effects while taking telavancin, which includes patients with kidney disease, congestive heart failure, hypertension (high blood pressure), diabetes, or heart rhythm problems like QT prolongation.

When taken correctly, telavancin can provide relief for patients with serious bacterial skin infections. Given by injection by a nurse or other healthcare professional, this medication can improve quality of life for patients with serious bacterial skin infections. To achieve these results, patients must work with their doctors to find the right dosage or combination of medications.