Telmisartan and Amlodipine (Oral)

Telmisartan and Amlodipine reduce the risk of heart attack and stroke in patients by lowering the blood pressure to relieve hypertension. Telmisartan and Amlodipine is a combination of two different medications that can be used together or alongside other medication.


Telmisartan and Amlodipine is a combination of medications that are used in the treatment of hypertension, which is also known as high blood pressure.

Patients with hypertension or high blood pressure put too much strain on the heart and the arteries. When this state continues for a significant amount of time it can stop the heart and arteries from functioning correctly and will rapidly increase risk of damage in the patient.

The blood vessels inside the brain, heart and kidneys can all be affected with the frequent result of strokes, kidney failure or heart failure. Lowering the blood pressure with Telmisartan and Amlodipine will reduce these risks and prevent strokes, heart attacks and kidney failure from occurring in the patient.

Telmisartan works by stopping the production of a chemical in the body that causes the tightening of blood vessels. As an angiotensin II receptor blocker (ARB), Telmisartan has the effect of relaxing the blood vessels and decreasing blood pressure within the patient. With the blood pressure lowered the lungs are able to transfer more oxygen into the blood, which is then transported to the heart to achieve better general health.

Amlodipine blocks the progression of calcium into the cells of the heart and blood vessels. As a calcium channel blocker (CCB), Amlodipine reduces the calcium content in blood vessels. In turn this relaxes them and relieves blood pressure. This again allows more oxygen to be passed into the blood and transported onwards into the heart.

This medicine is prescribed by doctors in tablet form.

This medicine is not a cure for high blood pressure. Instead it acts to relieve the high blood pressure by blocking natural processes from occurring within the body. To continue to benefit from this medication it must be taken as an on going medication for the rest of your life. Stopping treatment once started will cause your blood pressure to return to high levels and you will immediately be exposed to the dangers of high blood pressure and increased risk of heart attacks, kidney failure and strokes.

In order to reduce your blood pressure naturally so that you can cease treatment you will need to consider lifestyle changes including healthier eating, reduction of salt intake and exercise to promote weight loss. Without lowering your blood pressure through other means, you will not be able to reduce your risk and will need to keep taking Telmisartan and Amlodipine in perpetuity.

Telmisartan and Amlodipine should not be taken by pregnant women except in life-threatening situations. This medication has been shown to be harmful to fetus in the womb, but in certain cases treatment benefits can outweigh the risks to fetus development.

Condition treated

  • High blood pressure
  • Hypertension

Type of medicine

  • Telmisartan - Angiotensin II receptor blocker (ARB)
  • Amlodipine - calcium channel blocker (CCB)

Side Effects

Alongside lowering your blood pressure to relieve hypertension, Telmisartan and Amlodipine can have side effects that may impact your health. These unwanted side effects can often be mitigated and many do not require medical attention, but others do require that you seek immediate medical attention. The following side effects have been listed for regularity and severity. Other side effects may occur.

The following side effects should be reported to your doctor immediately that they occur:

Occurring commonly in patients

  • Bloating and/or swelling of the face or of the limbs
  • Body aches or pain
  • Chills when warm
  • Coughing
  • Difficulty experienced breathing
  • Ear problems including blockages
  • Feverishness
  • Headaches
  • Loss of voice and hoarseness
  • Nasal blockage
  • Rapid weight increase
  • Runniness of the nose
  • Sneezing
  • Sore or tickly throat
  • Tingling of the hands or feet
  • Unusual tiredness
  • Unusual weakness
  • Unusual weight gain
  • Unusual weight loss

Occurring less commonly

  • Bladder pain or soreness when full
  • Blood or clouding noticed in the urine
  • Blurry vision
  • Chest pains
  • Diarrhea
  • Difficult or painful passing of urine
  • Dizziness
  • Frequent urge to pass urine
  • General feeling of discomfort or illness
  • Joint pain
  • Loss of appetite
  • Lower back or side pain
  • Muscle aches and pains
  • Nausea
  • Nervousness or uncertainty
  • Pounding in the ears
  • Shivering
  • Slow or fast heartbeat
  • Sweating
  • Troubled sleep
  • Vomiting

Occurring only rarely

  • Abdominal or stomach pain
  • Arm, jaw or back pains
  • Black stools with an appearance of tar
  • Bleeding in the mouth
  • Blistering or loosening of skin
  • Blood in the urine or stools when passing
  • Burning or tingling feelings of the skin
  • Chest tightness or heaviness
  • Cold sweats
  • Confusion or disorientation
  • Constipation
  • Cough or hoarseness
  • Dark urine
  • Difficulty breathing or needing to take especially deep breaths
  • Difficulty swallowing
  • Dry mouth or feeling of dehydration
  • Extreme fatigue or excessive tiredness
  • Fast or irregular beating of the heart
  • Feeling of warmth or clamminess
  • Flushed or cracked skin
  • Fruit-like breath stench
  • Hives or other red swellings
  • Increased appetite
  • Increased sweat production
  • Increased thirst
  • Increased volume of diluted urine that will appear pale in color
  • Irregular heartbeat
  • Irritation inside the patient's mouth
  • Joint or muscle pain
  • Large swellings that may appear like hives. These can occur on many parts of the body including face, legs and sexual organs.
  • Lightheadedness, dizziness, or fainting
  • Loss of consciousness
  • Muscle cramps or stiffness
  • Pale, bluish-colored, or cold hands or feet
  • Pinpoint red spots on the skin
  • Rash
  • Redness, soreness or swelling of the gum
  • Redness, soreness, or itching of the skin
  • Severe or sudden headache or migraine
  • Sudden loss of coordination
  • Sudden slurring of speech
  • Swollen glands in the neck
  • Tightness in the chest
  • Trembling or shaking of the hands or feet
  • Unexplained weight loss
  • Unusual bleeding or bruising
  • Vomiting of blood
  • Weakness of your limbs
  • Weight gain
  • Yellow tinge to eyes or skin

Other side effects may occur that do not require medical attention. The follow side effects are not cause to contact your doctor, but if any side effects do become bothersome or are on going then you can inform your medical professional who may be able to help you to alleviate the effects that you are experiencing. If you need any advice in this matter then you can contact your healthcare professional.

Uncommon in occurrence

  • Acid stomach
  • Belching
  • Difficulty with mobility and stiffness of joints
  • Heartburn
  • Indigestion
  • Pain or tenderness around the eyes and cheekbones
  • Sleepiness or unusual drowsiness

Occurring only rarely

  • Abnormal dreams
  • Ankle, knee, or toe joint pain
  • Anxiety
  • Bad, unusual, or unpleasant aftertaste when eating
  • Bleeding after defecating
  • Blistering or irritation of skin
  • Bloody nose
  • Burning feeling in the chest or stomach
  • Burning, dry, or itching eyes
  • Changes in vision quality or appearance
  • Cold and clammy skin
  • Continuing ringing or other unexplained noises
  • Cough producing mucus
  • Cracked, dry, or scaly skin
  • Decreased sexual performance
  • Decreased sexual desire
  • Depression
  • Dry mouth
  • Earache
  • Excess air or gas in the stomach or intestines
  • Feeling of constant movement of self or surroundings
  • Feeling of warmth
  • Full feeling or bloating
  • Hair loss or thinning of the hair
  • Headache, severe and throbbing
  • Hearing loss
  • Hives or welts
  • Hyperventilation
  • Inability to have or keep an erection
  • Increased appetite
  • Irritability
  • Lack of feeling or emotion
  • Lack or loss of strength
  • Loose stools
  • Loss of memory
  • Redness of the skin
  • Redness or swelling in the ear
  • Redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • Restlessness
  • Tenderness in the stomach area
  • ¬†Toothache
  • Uncomfortable swelling around the anus or rectal irritation

Other side effects that are not listed here can possibly occur when taking the combined Telmisartan and Amlodipine. If you experience any other side effects inform your doctor and they will advise you on what to do.


This medication is not a cure for high blood pressure and as such should be administered alongside advice on how to lower blood pressure. Treatment for high blood pressure can include weight loss initiatives, changes in the types of foods that you eat, reductions in the amount of salt that is consumed and exercise. Your doctor will be able to advise you on how best to lower your blood pressure.

It is important to note that patients taking this medication will often feel fine and may think that they no longer need it. While this medication does lower blood pressure, it will not keep it low if you cease to take the medication. Under no circumstances should you cease to take the medication unless you are directed to do so by your doctor.

If you have not taken steps to naturally lower your blood pressure then failing to take this medication as directed will result in an increase of pressure and a returned heightened risk of strokes, heart attack, blood vessel disease and kidney failure.

This medicine should be taken with or without food at the same time every day.

The follow doses are guidelines only. Your doctor will determine the correct dose for you dependant on your weight, the strength of the medicine, your medical conditions and your blood pressure.

Do not change your dose unless instructed to by a doctor.

Typical doses:

  • Adults - 40mg of Telmisartan and 5mg of Amlodipine once per day. Dose can be adjusted up to a maximum of 80 of Telmisartan and 10mg of Amlodipine once per day.
  • Children - Use and dose to be determined by the doctor only.

If you miss a dose you should take it as soon as possible unless you are close to your next dose. You should never take a double dose. If you miss a dose completely return to your normal schedule and make note of when the dose was missed to inform your doctor at the next check up.


Different medications can interact with one another in the body. In some cases they should not be used together and in others the dose may need to be adjusted in one or both of the medications. Whenever you are being prescribed with a medicine it is vitally important that you inform your doctor of any and all other medications that you are taking. This includes any over the counter medications that you may be taking, herbal remedies and prescribed medications. Drug interactions that will occur have been listed below, but this may not be all inclusive so be sure to inform your doctor of all medications you take.

Use of Telmisartan and Amlodipine with any of the following medications is not recommended. If you are taking this medication then your doctor may wish to change one or more of the medications that you are being treated with.

  • Aliskiren

Use of Telmisartan and Amlodipine with any of the following medications would not normally be recommended. In some cases treatment with both medications may be required and your doctor may wish to prescribe both together. In such cases the dose of one or both may or may not be altered.

  • Trimethoprim
  • Trandolapril
  • Telaprevir
  • Tegafur
  • Tacrolimus
  • Simvastatin
  • Ramipril
  • Quinapril
  • Piperaquine
  • Perindopril
  • Moexipril
  • Lithium
  • Lisinopril
  • Lacosamide
  • Idelalisib
  • Fosinopril
  • Enalaprilat
  • Enalapril
  • Eliglustat
  • Droperidol
  • Domperidone
  • Digoxin
  • Dantrolene
  • Cyclosporine
  • Conivaptan
  • Clopidogrel
  • Clarithromycin
  • Ceritinib
  • Captopril
  • Benazepril
  • Atazanavir
  • Amiodarone

Using Telmisartan and Amlodipine with the following medications can increase the side effects experienced from one or both of the medications. You may still be prescribed both medicines by your doctor.

  • Valdecoxib
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Proquazone
  • Propyphenazone
  • Propionic Acid
  • Proglumetacin
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Indinavir
  • Ibuprofen
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Droxicam
  • Dipyrone
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Clonixin
  • Choline Salicylate
  • Celecoxib
  • Bufexamac
  • Bromfenac
  • Amtolmetin Guacil
  • Acemetacin
  • Aceclofenac

Medications can also react differently in people who have existing medial conditions and in some cases medication can worsen other conditions. It is vitally important that you inform your doctor if you if you have or have had any medical conditions that may affect treatment. The following conditions are particularly important to share with your doctor.

  • Angina
  • Electrolyte imbalance
  • Fluid imbalance
  • Recent heart attack
  • Heart problems
  • Kidney problems

In patients with kidney problems the medication can stay in the body for longer and make side effects worse.

  • Severe congestive heart failure - Kidney failure can be caused in these patients
  • Diabetes patients or those with kidney problems - These patients may be taking Aliskiren. This drug should not be used alongside Telmisartan and Amlodipine.
  • Heart or blood vessel disease - The risk of chest pain and heart attacks will be increased.
  • Live disease - Side effects can be increased because the medication will be removed from the body less quickly.


Before taking this medication you should consider the risks in relation to the potential benefits that you will receive from doing so. Discuss the potential positives and negatives with your doctor before you begin treatment. So that your doctor has all of the relevant information make sure you tell them about any existing conditions and medications that you have. You should also consider and share the following:

Allergies - If you have any allergies then they may react to the medication. Inform your doctor if you have ever reacted badly to any medication that you have received in the past. Allergies to dyes, foods, preservatives, animals and other substances are also relevant to share, particularly if they are severe.

Pregnancy - Telmisartan and Amlodipine work by blocking natural processes in the body and as such should not be used in pregnant women where this can be avoided. Studies have demonstrated a real risk to the fetus in pregnant women. In cases where there is a threat to life, treatment benefits can still outweigh the potential risk of undergoing this treatment. In some cases this medication may be administered to a pregnant woman.

Breastfeeding - There are no adequate studies to determine the risk of breastfeeding when taking Telmisartan and Amlodipine. Weigh the risks of doing so with your doctor against the benefits of doing so.


Always keep medication out of the reach of children.

Do not keep the medication once it has expired. Your doctor will be able to inform you of how best to dispose of the medication that has not been used.

Keep the medication in a closed container at room temperature. Telmisartan and Amlodipine should be kept out of direct light and away from both moisture and heat.

Prevent the medication from freezing.

Keep the tablets in the blister packs until you are ready to take them.


Telmisartan and Amlodipine are used to treat high blood pressure or hypertension in patients. This is a combination of 2 medications that work to inhibit the production of different chemicals in the body. Both have the effect of relaxing the blood vessels and in doing so they are effective in lowering the blood pressure temporarily.

In order to keep the blood pressure low the patient will need to keep taking the medication in perpetuity unless they can naturally lower their blood pressure through healthier living.

This medication should be prescribed along with advice on how to lower blood pressure by making changes to the food consumed, reducing the level of salt intake, achieving weight loss and exercising. Your doctor will be able to give you advice on how you may be able to lower your blood pressure and stop taking Telmisartan and Amlodipine.

Having a high blood pressure puts you in serious risk of stroke, heart attacks and kidney failure so it is vital that you do not stop taking Telmisartan and Amlodipine unless instructed to by a doctor. Remember that Telmisartan and Amlodipine is not a treatment for high blood pressure, instead it works to lower blood pressure temporarily. This means that as soon as you stop taking this medication your blood pressure will rise one again and put you at risk of the associated conditions once again.

There has been shown to be a serious risk to fetus that are exposed to Telmisartan and Amlodipine in the womb. Pregnant women are advised against the use of these medications except in cases where their life is threatened. In certain cases use of the medication can outweigh the risks and it may still be prescribed. If you become pregnant whilst taking this medication you should inform your doctor as soon as it is possible to do so to discuss the options.

Telmisartan and Amlodipine are administered in tablet form and can be self-administered by the patient. The tablets are only available with a prescription and the patient will need to undergo regular check up when taking the medication to ensure that it is working effectively and that no unwanted side effects are occurring.

Last Reviewed:
December 22, 2017
Last Updated:
April 05, 2018
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