Terconazole (Vaginal)

Terconazole reduces vaginal itching, burning, and discharge that can occur with yeast infections, and works by halting the growth of fungus (yeast) that's behind the infection.


Terconazole is a medicine that fights fungal infections, specifically vaginal yeast infections, and is available under several brand names, including Zazole, Terazol 3, and Terazol 7.

It also may have other uses besides the ones discussed here.

Before using Terconazole, follow all directions found on your medicine pack and label. Tell all your healthcare professionals about all medicines you're using, as well as all allergies and medical conditions you suffer from.

You shouldn't use Terconazole if it causes allergies.

Don't use this medication if you've never developed a vaginal yeast condition that has been verified by a doctor.

To ensure that Terconazole is safe for use, let you doctor know if you have:

  • Vomiting, chills, fever
  • Vaginal discharge with bad odor, pelvic pain
  • If you're experiencing vaginal discomfort or itching for the first time
  • If you believe you may have had exposure to HIV

It's unknown whether Terconazole affects unborn babies. Notify your physician if you're pregnant.

It's unknown whether Terconazole comes into contact with breast milk or if it may affect a nursing child. However, you're advised not to breastfeed while using Terconazole.

Terconazole should not be given to anyone younger than 18 without medical advice.

Conditions treated

Type of medicine

  • Azole antifungal

Side effects

Menstrual cramps, headache, or increased urethral or vaginal pain/itching/burning may occur. If you have any of these effects which persist or worsen, report them to your healthcare provider promptly.

Bear in mind that your physician has prescribed Terconazole because he/she has deemed it to have more benefits than risks to you. Many people who use Terconazole don't experience serious side effects.

Here are some possible side effects. They may, however, also be signs of another more serious condition like pelvic inflammatory disease or bacterial vaginosis that may need a different treatment. If you feel any of these rare but severe side effects, make sure to report it to your doctor promptly: flu-like symptoms such as chills or fever, foul-smelling vaginal discharge, and stomach or abdominal pain.

It's very unlikely that Terconazole can cause an extremely serious allergic reaction, but seek treatment right away in case it happens. Signs of a very serious allergy may include rash, troubled breathing, severe dizziness, and swelling or itching of the face or throat or tongue.

This isn't an all-inclusive list of possible Terconazole side effects. Contact your healthcare provider if you experience other effects.


Use Terconazole exactly as ordered by your primary healthcare giver. Don't take more or less of it and don't use it more times than your physician ordered.

This medicine usually comes with instructions. Carefully read these instructions and follow them. If you have questions about the medication, ask your doctor.

Don't take Terconazole orally. It is to be used in your vagina only.

Terconazole comes in the form of a vaginal suppository and cream. Each form has an applicator, which is used for measuring and applying the medication. The cream also comes in pre-filled applicators, with each containing a single daily dose of the medicine. You can insert the suppository with your finger if you choose to.

Wash your hands prior to and after applying the vaginal cream or suppository.

Terconazole is normally applied once per day at bedtime for three to seven successive days. Follow your physician's directions.

Use Terconazole for the entire prescribed period of treatment. Your symptoms may ease before your infection clears up completely. Skipping doses can also increase your chances of another infection that's not responsive to antifungal medicine.

If your symptoms haven't improved within 3 days or you still have the symptoms more than 7 days later, call your doctor. Recurring yeast infections that don't respond to treatment may indicate a more serious medical problem.

Terconazole vaginal suppositories have ingredients that may damage a diaphragm. Don't use this birth control method during treatment with vaginal suppositories.

Some cream applicators are meant to be used only once. Therefore, discard such an applicator after a single use, even if it has some medication left in it.

Your partner should see a physician if he develops itching, redness, or other form of discomfort in the penis. These could be signs that your partner has caught your yeast infection.

Don't stop using Terconazole if your monthly period starts during treatment. Use sanitary pads instead of tampons.

During the day, Terconazole can spill out of your private area. Protect your clothing by wearing a sanitary pad, instead of a tampon.

The dose of Terconazole will vary with patients. Make sure to follow the instructions on the label or your doctor's orders. This information only includes the standard doses of Terconazole. If you're taking a different dose, don't adjust it unless your physician tells you to.

The amount of Terconazole you take depends on its strength. In addition, the time between each dose, the duration in which you take Terconazole and the number of Terconazole doses you take daily depend on the condition you're treating.


The effects of certain medicines can change if other medicines or herbal products are used at the same time. Therefore, your risk for severe side effects may increase or your medications may not work properly.

Drug interactions can happen, but they don't always happen. Your healthcare professional can often manage or prevent interactions by closely monitoring or changing how you take medicines.

To help your healthcare giver provide you with the best possible care, make sure to tell them about all the medicinal products you're using currently (e.g. herbal products, over-the-counter drugs, and prescription drugs) before beginning treatment with Terconazole.

While using Terconazole, don't change, discontinue, or start any other medication dosage without your physician's knowledge.

Some products that could increase the chances of having yeast infections include corticosteroids (e.g. prednisone), antibiotics, and medicines that suppress your immune system (e.g. methotrexate, and cyclosporine). List all products you're using. Share this list with your healthcare providers to lower your risk for severe side effects.

Avoid sex during treatment with Terconazole, unless your physician says that you can.

Don't use a vaginal douche, tampon, or any other vaginal products when using Terconazole.

Avoid wearing synthetic, tight-fitting clothes such as panty hose or nylon underwear that doesn't allow air circulation. Instead, wear loose-fitting clothes made of natural fibers, especially cotton, until your infection clears up.

It is very unlikely that other medicines you inject or take orally will affect the Terconazole you use in your vagina. Many drugs, however, may interact when used together.

Other medications not listed above can interact with Terconazole. Tell your prescriber or doctor about all the drugs as well as supplements you're using. As caffeine, nicotine from cigarettes, street drugs, or alcohol can interact with many medications and affect their action, you should tell your pharmacist if you use any of them.


In choosing to use a drug, you must weigh the risks of taking the drug against the positives it will bring. This is something you and your physician should discuss. For Terconazole, here's what you need to consider.

Before using Terconazole, notify your pharmacist/doctor if you have allergies to the medication, or to other antifungal medicines (e.g. fluconazole or clotrimazole), or you suffer from any other allergies. There may be inactive substances in Terconazole, which may cause allergies as well as other issues. To get additional medical advice, talk to your pharmacist.

Also inform your healthcare giver if you have other kinds of allergies, such as allergies to animals, foods, dyes, or preservatives. For over-the-counter products, check the ingredients on the package or label carefully.

Before using Terconazole, tell your pharmacist and primary healthcare giver your medical history, particularly of conditions like immune system disorders (e.g. HIV/AIDs), and recurrent vaginal yeast infections (at least 4 per year).

Before undergoing an operation, inform your dentist or doctor or other healthcare provider about all the medications you use (such as herbal medicines, prescription medicines, and nonprescription medicines).

Before you have sex with your other half, ask your physician whether you can do so while taking this medication. The vaginal suppository (not the vaginal cream) can break rubber products like latex condoms, cervical caps, and diaphragms) and cause failure. This may result in pregnancy. Thus, never use these products while taking the suppository form of Terconazole and for three days after finishing your treatment. Consult your physician about other barrier protection methods of birth control (e.g. polyurethane condoms) at this time or apply the cream variety of Terconazole.

During pregnancy, Terconazole should not be used except when it's really necessary. Be sure to talk about the pros and cons of taking Terconazole during pregnancy with your doctor. Pregnant women should be extra careful when handling the vagina applicator. It is recommended that this product not be used during the first trimester of pregnancy.

It's unclear whether breast milk comes into contact with Terconazole. The effect of the medication on a nursing child is also unknown. Before breastfeeding, make sure to talk about this medication with your doctor.

Don't give anyone else Terconazole, even if they're exhibiting symptoms similar to yours. It can be risky for anyone to use this medication if their physician hasn't prescribed it.

Adequate research hasn't been done on the link between Terconazole effects and age in children. The drug's efficacy and safety on children hasn't been determined as well.

Studies done thus far haven't demonstrated problems specific to older people that would restrict the usefulness of this medication among the elderly.

Make sure that Terconazole does not get in your mouth, nose, or eyes. If it gets in any of these parts, rinse with plenty of water.

Avoid exposure to tanning beds or direct sunlight. Terconazole can easily cause you to be sun burnt. When you're outside, wear protective attire and use sunscreen of at least SPF 30.

Vaginal medications will usually spill out of the vulva during treatment. To protect your clothing from the leaks, wear a sanitary napkin or mini-pad. It's not recommended to use tampons because they can soak up Terconazole.


Keep Terconazole tightly closed in its original container.

Keep Terconazole away from your pets and children.

Keep Terconazole away from too much moisture and heat (not in the lavatory or kitchen)

Keep Terconazole at room temperature.

Discard any outdated medicine or one that you don't need.

Talk to your local pharmacist about the right way to dispose of Terconazole.


It's crucial that your physician monitor your progress after finishing treatment. This will ensure that the disease is done away with for good and your doctor can check for undesirable effects.

If your symptoms worsen or they don't improve after treatment, see your doctor promptly.

Terconazole may cause some serious allergies, including anaphylaxis. This is a life-threatening condition which requires immediate treatment. Call your doctor promptly if you suffer a peeling, red, or blistering skin rash, ulcers or sores in the lips or mouth, itching, trouble swallowing, trouble breathing, or any sort of swelling of your mouth, face, or hands while using Terconazole.

If you're allergic to any kind of seeds or nuts, let your physician know. Some products do contain nuts.

Don't use Terconazole if you have stomach pain, foul-smelling vaginal discharge, or fever. Talk to your primary healthcare provider.

Don't use the cream version of Terconazole for itching caused by a different health problem to vaginal yeast infection. Speak to your doctor.

Some medicines may come with an extra patient information leaflet. Please ask all your healthcare providers any questions you may have about Terconazole.

Dry outside the vaginal area thoroughly after swimming, bathing, or showering. Change out of damp workout clothing or wet bathing suits immediately.

Don't scratch the area affected. Doing so can worsen the irritation and make the infection spread.

If there's an overdose or you suspect there has been one, get medical attention promptly or contact your nearest poison control service. Be willing to tell or demonstrate what was ingested, when it happened, and how much.

Last Reviewed:
December 25, 2017
Last Updated:
April 05, 2018
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