Thiothixene (Oral)

Thiothixene is essentially an antipsychotic drug that works by affecting chemical substances in the brain known as neurotransmitters.


Thiothixene belongs to a class of drugs known as antipsychotics, which are used for treating schizophrenia and other mental disorders not discussed here. Some of the most common symptoms exhibited by patients suffering from schizophrenia include having unorganized thoughts, hallucinations (hearing or seeing things that don't exist), being delusional, and having aggressive behavior towards oneself or others.

As an antipsychotic medication, thiothixene works by affecting certain chemicals in the brain known as neurotransmitters. This medicine helps patients with mental disorders such as schizophrenia to lead a normal life. If you suffer from schizophrenia, this medication can help you think clearly, be less anxious and act normally instead of being hostile and aggressive towards other people. However, thiothixene cannot be used treat mental disorders related to dementia. The medication can cause death if it's used to treat dementia symptoms, especially in older individuals. The medicine can only be prescribed by a doctor.

Conditions treated:

  • Schizophrenia

Type of medicine

  • Antipsychotic

Side effects

Thiothixene is usually taken orally in the form of capsules, liquid, mixed solution or tablets. If used correctly as prescribed by a healthcare professional, the medication is effective in treating schizophrenia symptoms and can also cure other mental illnesses. However, just like any other medication, taking thiothixene will certainly produce several unwanted effects. The side effects you'll experience after taking this drug may differ with another patient dealing with the same condition. However, most schizophrenia patients experience a number of common side effects. Some side effects may require the urgent intervention of the doctor before things get out of hand. Speak with your doctor as soon as possible if these unwanted effects occur after taking this medicine.

  • Cough
  • Dizziness
  • Fast heartbeat
  • Difficulty with swallowing
  • Hives
  • Itching
  • Shortness of breath
  • Swelling of face, eyelids, lips, or tongue
  • Skin rash
  • Unusual tiredness or weakness
  • Wheezing
  • Tightness in the chest
  • Abdominal pain
  • Bleeding gums
  • Back or leg pain
  • Swelling of the hands, arms, face or feet
  • Blurred vision
  • Blood in stool or urine
  • Bloody or tarry stool
  • Chest pain
  • Confusion
  • Chills
  • Dark urine
  • Clay-colored stools
  • Convulsions
  • Cough or hoarseness
  • Fainting
  • Difficulty with breathing
  • Dizziness, lightheadedness or faintness when getting up quickly from a sitting position or lying position
  • Irregular heartbeat or pulse
  • Fever
  • Body swelling
  • General feeling weakness or fatigue
  • Headache
  • High blood pressure
  • Low blood pressure
  • Increased sweating
  • Inability to move your eyes
  • Inability to sit still
  • Loss of appetite
  • Increased blinking
  • Lip smacking
  • Loss of bladder control
  • Mask-like face
  • Loss of balance control
  • Nausea or vomiting
  • Lower back or side pain
  • Pale skin
  • Need to keep moving
  • Nose bleeding
  • Painful urination
  • Restlessness
  • Red spots on the skin
  • Swelling of the cheeks
  • Worm-like movements of your tongue
  • Seizures
  • Severe muscle stiffness
  • Rapid weight gain
  • Slowed movements
  • Slurred speech
  • Restlessness
  • Shuffling walk
  • Sore throat
  • Sores
  • Ulcers
  • Sweating swollen glands
  • Tiredness
  • White spots on the lips or in the mouth
  • Jerky movements of your head face or neck
  • Trembling of hands
  • Tingling of the feet or hands
  • Difficulty with breathing, swallowing or speaking
  • Unexplained bleeding
  • Unexplained bruising
  • Uncontrolled chewing movements
  • Vomiting of blood
  • Unusual weight gain
  • Uncontrolled movements of body
  • Unpleasant breath odor
  • Unusual bleeding or bruising
  • Unusual facial expressions
  • Unusual weight gain
  • Unusual weight loss
  • Yellowing of the skin or eyes

Seek emergency treatment if any of these overdose symptoms below occur while using thiothixene.

  • Symptoms of overdose
  • Change in consciousness
  • Drowsiness
  • Loss of consciousness
  • Depression
  • Sudden jerky movements of the body

Some unwanted effects of taking thiothixene may not necessarily require medical help. Normally, these side effects disappear as you continue to get treated and your system adjusts to the drug. The doctor can also advise you on ways to prevent or reduce the severity of such side effects. Consult your doctor if the side effects listed below persist:

  • Irregular menstrual periods
  • Anxiety
  • Diarrhea
  • Constipation
  • Decreased libido
  • Hives or welts
  • Dry mouth
  • Hyperventilation
  • Extreme thirst
  • Increased appetite
  • Inability to have an erection
  • Increased thirst
  • Watering of mouth
  • Skin sensitivity to sunlight
  • Increased weight
  • Increased sweating
  • Nervousness
  • Irritability
  • Redness of the skin
  • Stuffy nose
  • Severe sunburn
  • Swelling of the breasts
  • Sleeplessness
  • Stopping of menstrual bleeding
  • Unusual milk production

The above mentioned side effects may not be a complete list of the unwanted effects as provided by the manufacturer of thiothixene. For more info about other risks associated with taking thiothixene, ensure that you check out the official information provided by the company producing this medication. You can also request a definitive list from your doctor or pharmacist.


Dosage requirements for thiothixene are the same for adults and children above the age of 12. Adults suffering from mild schizophrenic episodes are required to take an initial dose of 2 mg orally 3 times per day; they should then proceed to take a maintenance dose of 15 mg per day.

The dosage amount is usually increased for patients with severe symptoms. The initial dose for such patients is normally 5 mg taken orally twice per day, while the maintenance dose is recommended to be 20 or 30 mg per day. The maximum dose that a doctor can prescribe in any situation is 60 mg of the medicine per day.

The doctor can adjust dosage amounts depending on the severity of symptoms in a patient. But all patients have to begin with small doses before dosage amounts can be increased. Remember that children above the age of 12 are given the same dose as adults.

If you happen to miss a dose, take one as soon as you remember. If the time for next dose is near, continue with your dose schedule but do not take a double dose to compensate for the missed dose. Call the poison control center in case you overdose this medication.

Drug Interactions

The general rule of the thumb is not to use two drugs that interact with each other. But there are several cases where medications have to be combined for your benefit even if the interactions produce unwanted side effects. The doctor may decide to alter dosage or introduce more precautions in order to deal with your situation.

When using thiothixene, ensure that you inform the doctor if you are taking other drugs. Such information is critical if you don't want to suffer more side effects caused by two or more medications interacting. The following medicines should not be used in combination with thiothixene.

  • Bromopride
  • Metoclopramide

Using thiothixene together with the drugs mentioned below is not advised but could be necessary in certain circumstances. If both drugs are prescribed as a combination, your doctor can alter the dosage amount, or the schedule of taking both medications.

  • Alfentanil
  • Buprenorphine
  • Butorphanol
  • Dihydrocodeine
  • Codeine
  • Fentanyl
  • Hydromorphone
  • Lithium
  • Hydrocodone
  • Milnacipran
  • Morphine
  • Meperidine
  • Methadone
  • Morphine Sulfate Liposome
  • Oxycodone
  • Pentazocine
  • Oxymorphone
  • Sufentanil
  • Remifentanil
  • Tiotropium
  • Tapentadol
  • Zotepine
  • Tramadol

Using this medication in combination with this drug can make certain side effects severe. But the combination may be helpful to you.

  • Betel Nut

Other interactions

Thiothixene shouldn't be used at the same time while eating certain kinds of food because bad interactions can happen. The use of tobacco or alcohol can also cause interactions with this medication. Talk to your healthcare provider to provide you with a list of foods you should avoid when taking thiothixene.

Medical issues

If you are suffering from other medical conditions, then the use of thiothixene will certainly cause several unwanted effects. Consult your physician if you have any of the following medical issues.

  • Bone marrow or blood problems like agranulocytosis, leukopenia, and neutropenia
  • Depression with symptoms such as severe drowsiness or loss of consciousness
  • Circulatory collapse
  • Breast cancer
  • Eye problems such as lenticular pigmentation or pigmentary retinopathy
  • Heart or blood vessel ailments
  • Hyperprolactinemia
  • Neuroleptic malignant syndrome (NMS)
  • Liver disease
  • History of Seizures

The doctor will decide whether to continue administering thiothixene or choose other medications if you have other medical issues.


Inform your pharmacist or doctor if you suffer allergic reactions to thiothixene, phenothiazines like chlorpromazine, perphenazine, fluphenazine, thioridazine, trifluoperazine, prochlorperazine (Compazine) and promethazine (Phenergan); or any other medications.

This medication can be used to remedy other mental conditions. The doctor may decide to use a combination of drugs in order to remedy serious mental disorders. However, thiothixene must never be used to treat patients suffering from dementia. The medicine can cause death if used to ease the symptoms of dementia, particularly in older people.

Tell your physician about all the prescription,non-prescription drugs, nutritional supplements and vitamins you are taking or intend to use. Your doctor may decide to change your dosage or frequency of use if you are using other medications to treat any of the following conditions:

  • Depression
  • Anxiety
  • High blood pressure
  • Irritable bowel disease
  • Mental illness
  • Motion sickness
  • Parkinson's disease
  • Ulcers
  • Urinary problems
  • Seizures

Inform your doctor about all the herbal solutions you are taking.

Tell your doctor if you have previously suffered from any disease that affects your blood cells. Your physician will likely to advice you not to use thiothixene if you have a history of any blood cells disease.

Inform your physician immediately if you suffer from seizures, heart disease or cancer. The doctor may have to alter your dose or change the medication altogether. If you experience alcohol withdrawal symptoms, it's a good idea to inform your doctor. He or she will decide if thiothixene is appropriate for your condition or not.

It is important to inform your doctor if you are pregnant and you are using thiothixene. This medicine is known to affect babies after delivery; particularly if it was taken during the last trimester. The doctor will analyze your condition and decide if it is appropriate to use thiothixene.

If you are planning to undergo a dental surgical operation, inform your physician prior to taking this medicine.

Thiothixene makes patients drowsy and can affect one's movements as well as thinking capacity, especially at the start of treatment. As such, you should not operate any machinery or drive a car while taking this medication.

Alcohol is known to worsen schizophrenia symptoms, thus should be avoided if you are taking this medication. In some cases, alcohol can be permitted by the doctor provided it's used responsibly. Consult your doctor about the safe use of alcohol if you are taking this type of drug.

Thiothixene can make your skin sensitive, especially if you are exposed to sunlight for a long time. As a result, do not get exposed to sunlight for a long time if you are using this medication. Wearing protective clothes and sunglasses can be of great help.

If you plan to exercise intensively, then it's crucial to speak to your doctor for advice. Remember your body may not be able to cool down naturally if you are using this medication because exercise generates heat in your system.

Beware of getting up fast if you are in a lying position because thiothixene can cause fainting, lightheadedness or dizziness. However, such effects are more pronounced at the beginning of your dose and shouldn't be a risk once your body adjusts to this medicine. Healthcare experts advise that you practice getting up slowly all the times while using medicine to avoid the mentioned side effects. Speak with your doctor if you continue to experience dizziness or faintness even after using the medication for a long period of time.


Keep this medicine in a safe place and away from the reach of children. You should ensure that the container is closed properly to avoid the medication from spilling out. The medication should ideally be stored at room temperature and not areas in your house like the bathroom where there may be moisture or heat. Unneeded medicines ought to be disposed properly to prevent pets, kids or other people from taking them. Flushing this medication down the toilet is discouraged.

You can safely dispose of your unneeded medicine through take-back programs in your area. You can ask your pharmacist for more info about take-back programs in your locality if you want to safely dispose of unused medication but you are stuck. More information on how to safely throw this medicine and others can be found on FDA's Safe Medicine portal.


Thiothixene is classified as an antipsychotic medication used for treating schizophrenia. It can also be used to remedy other mental disorders alone or together with other drugs. Schizophrenia is a mental illness that is characterized by patients showing symptoms such as hallucinations (Seeing or hearing stuff that does not exist), showing aggressive behavior towards others, being in a state of delusion and having unstructured thoughts.

Thiothixene works by positively affecting certain chemical substances in the brain. After taking his medicine, schizophrenic patients begin to think clearly, become less anxious and reduce aggression. In short, taking this medication can help a schizophrenia patient lead a normal life once again. However, it's crucial to know that the medication shouldn't be used to treat people suffering from dementia, as it can cause severe side effects that can result in death.

Taking thiothixene usually produces common side effects like dry mouth, drowsiness, nausea, vomiting, constipation, restless feeling, fast heart rate, change in appetite etc. These unwanted effects should ease after some time once the body adjusts to the medication but if they persist, talk to your doctor for help.

Seek quick medical intervention if you notice any allergic reaction such as hives, swelling on face, swelling of lips or tongue while using thiothixene. Cease using thiothixene and get help from your doctor as soon as possible if you experience uncontrollable movements on your face, eyes, tongue, legs or arms. Additionally, you should stop using the medication if you suffer from seizures, lightheadedness, swollen gums, sore throat, mouth sores, stiff muscles and high fever.

Thiothixene is primarily offered in capsules and taken orally. The medication should be taken three times a day. The doctor will prescribe a small dose initially, then gradually increase the dosage amount depending on how you respond to treatment

Inform your doctor about all the prescription and nonprescription medication you are using to prevent drug interactions. But in some cases, the doctor may have to prescribe drugs that interact with each other for treatment to be effective. Consult your doctor if the medicine causes allergic reactions or serious side effects that can endanger your life.

Last Reviewed:
December 23, 2017
Last Updated:
April 23, 2018
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