Our body naturally produces the protein, Thrombin, in order to aid in healing and blood coagulation (blood clotting).
There is, however, a synthetically produced version of Thrombin that surgeons occasionally use to regulate mild bleeding and oozing.
Manufacturers use a genetically modified CHO cell line to create the synthetic version in labs. In the United States, this artificial Thrombin is known as Recothrom. This subset of Thrombin, in particular, may be derived from snake and hamster proteins.
In essence, Thrombin Human, Recombinant stimulates blood platelets and puts in motion the transformation of fibrinogen to fibrin. Thrombin Human, Recombinant ultimately supports the blood clotting process within the human body.
All medications carry side effects. Thrombin Human, Recombinant is no different.
Some of these side effects typically dissolve with time, however, it's always a good idea to tell your doctor if you develop any of the above side effects as these could be signs of Anaphylaxis shock.
There have been less reported incidences of the following side effects after taking Thrombin Human, Recombinant:
These in large part apply to irritation at the incision site.
When most people hear the word "topicalâ€, a gel or cream often comes to mind. Thrombin Human, Recombinant, however, is classified as a Lyophilized Powder. It was approved by the FDA for mild hemorrhaging in 2008 and is intended for topical applications only. It should never be injected into the circulatory system as this could lead to thrombosis.
The determined dose is usually based on a number of variables including:
The powder form of Thrombin Human, Recombinant can be directly applied to customary surgical incisions, including:
Thrombin Human, Recombinant is exclusively administered by trained healthcare workers in hospital, dental, or outpatient settings during or after surgery. The most standardized dosage used today range from:
Important: The powder should never be injected into the incision or any other area of the body.
The extent of the bleeding will also play a role in the dosage given by medical providers. For example:
As a safety measure, healthcare workers will use a spray or sponge to apply the solution directly onto the incision. The FDA recommends using an absorbable gelatin sponge for best results.
Read the instructions on the sealed package carefully before completing the dose. The standard instructions for use include:
Your surgeon should be aware of any medications you may be taking, including any over-the-counter drugs.
It is also vital that you discuss any lifestyle habits that could negatively interact or affect the outcome of using Thrombin Human, Recombinant. Some examples include telling your doctor if you happen to smoke tobacco or are a habitual drinker.
As Thrombin Human, Recombinant is derived from protein, it's important to tell your doctor before surgery if you have ever had any allergic reactions to animal products, especially hamster or snake proteins.
Thrombin Human Recombinant may cause Anaphylaxis, which is considered to be a fatal condition if it's not treated in a timely manner.
Some of the most common telltale signs of Anaphylaxis include:
If any of these symptoms develop after taking Thrombin Human, Recombinant, inform your nurse and/or doctor on duty immediately. Most healthcare facilities are equipped with an emergency dialer close to patients' beds and inside bathrooms for these very purposes.
Any other past allergic reactions should be noted in your medical history, and in particular, any sensitivities to any other foods, dyes, and preservatives.
Certain underlying medical conditions may also affect the way Thrombin Human, Recombinant works. The most widely studied negative interaction with Thrombin and an underlying condition is the presence of significant bleeds.
Thrombin Human, Recombinant is a class of drug that is approved for minor bleeds only. It should never be used to stop major bleeds, otherwise known as brisk arterial bleeding.
Adults and children who have been given Thrombin Human, Recombinant should be watched closely after administration for any negative side effects that could develop. Some side effects that require immediate medical attention include:
There have been no archives of adverse effects when Thrombin Human, Recombinant is used in senior or minors, except infants younger than four weeks old.
For nursing or expecting mothers, no sufficient research has been conducted to determine benefits vs. risks. Medical workers should therefore weigh both variables before coming to an assumption on the best course of treatment for patients.
Before administering the prescribed dosage, healthcare workers should always examine the package. If there are any signs of tampering, do not use. The vial should be handled with clean and dry hands, and as a standard practice, always wear medical-grade gloves when administering the medicine to patients to prevent the risk of transmission of infectious diseases.
The best practices for storing medicines at home, including topical products, is in cool and dry areas.
Thrombin Human, Recombinant is recommended for single and immediate use only. However, it can be refrigerated for up to 3 hours after opening in temperatures ranging from 2-8 degrees Celsius. Ask an authoritative figure if you are unsure of how to properly store the medicine.
Thrombin Human, Recombinant treats minor hemorrhaging during surgery. It therefore falls in the class of drugs known as surgical hemostats.
The human body produces thrombin naturally, and it is considered a critical protein for blood clotting purposes. After surgery, however, some patients may need a boost to speed up the healing process, and this is where synthetically derived Thrombin Human, Recombinant comes in.
Generally, the manmade version is sourced from snake and hamster proteins, and for this reason, it is critical to inform surgeons of any past allergic reactions to animal products as well as dyes or preservatives.
The most common concerns when taking Thrombin Human, Recombinant is hypersensitivity reactions or anaphylactic shock, as it is a synthetically produced protein.
Both children and adult patients should be closely monitored after administering the topical medicine to the incision, especially those who have had any history of allergies.
Due to allergic risks, doctors will weigh patients' full medical history before prescribing the drug.
Generally speaking, however, using Thrombin Human, Recombinant has been proven to successfully treat minor bleeds as it promotes the speedy coagulation of blood. It should only be administered by a trained health professional and should never be injected into the circulatory system.