Tioconazole (Topical)

Tioconazole, the topical medicine used to treat fungal and yeast infections, comes in both cream and ointment that can be applied directly to the skin.


Tioconazole is an anti-fungal medicine that treats yeast infection and other skin conditions caused by fungus and yeast. It treats the infections by killing the fungus or the yeast. It also prevents its growth by interfering with the production of the substance crucial to its development.

It is generic and there are several brand names depending on the medical conditions and the countries in which they are available. The brand names for this medicine in Canada include Gyne Cure, Troysd Af, and Trosyd J. The American brand names include Vagistat and Monistat. Tioconazole belongs to the Imidazole class. It only works against fungal infections not bacterial or viral infections.

Patients can obtain it with or without prescription depending on the infection. Either way, you can buy it at drugstores or at grocery stores in the pharmacy section. Because it is a self-administered medication, you do not have to rely on healthcare practitioners to administer it to you like you would with injections.

Conditions Treated

Type of Medicine

  • Cream (various fungal skin conditions)
  • Ointment (vaginal yeast infection)

Side Effects

Side effects for tioconazole can be both similar and different regardless of the medical conditions that it treats. The overall side effects are the less common ones which are burning, itching, redness, skin rash, and swelling. Dermatitis can occur in patients who are treated with the topical nail solution; however, the nail cream is not available in the U.S.

For the anti-yeast infection tioconazole, using it may result in a headache and the burning, itching, or pain in the vagina or in the urethra. There are also rare side effects including skin rash, hives, and the burning or the irritation of the sexual partner's penis. You may also experience the pain or the trouble when urinating and stomach or vaginal pain. Local side effects of burning, pain, dryness, and irritation have been commonly reported in 7% of the treated patients.

On a positive note, severe allergic reactions to tioconazole are rare and most patients who receive the treatment do not experience serious side effects. It is important to converse with your provider about the potential side effects in order to prepare and protect yourself against them.


For yeast infections, you should only use one full application of tioconazole at bedtime. This is the normal amount of dose needed to take the medicine safely. You must follow the directions on the label or use it as prescribed by your physician. Once you start using the ointment, it will start making some improvements on the symptoms after one day. It may take up to seven days for the treatment to completely eradicate the symptoms.

Since it is a single-use medicine, you should discard it properly after using it once even though there may be some ointment left in the container. It should also be discarded when it is past its expiration date. It is not possible to miss a dose of the tioconazole vaginal cream because you're only using it once. It is also impossible to overdose on it for the same reason.

For other fungal or yeast infections, the amount of the medication taken depends on several factors including its strength, the number of doses, and the length of time you take the medicine. It also depends on the type of fungal or yeast infections that it treats as you will see in the list below:

  • Body ringworm and the yeast infection of the skin
    • Twice a day for 2-4 weeks
  • Athlete's Foot
    • Twice a day for up to 6 weeks
  • Groin ringworm
    • Twice a day for up to 2 weeks
  • Sun Fungus
    • Twice a day 1-4 weeks

The above dosage list is for the adults. Children can receive the tioconazole too, but their pediatrician must decide the dosage amount.

If you miss a dose of tioconazole, apply it as soon as possible. If it's almost time for the next dose, you should skip the missed dose and take the next one. If you use it to treat the vaginal yeast infection, do not double the dosage.

As for the proper use, you need to apply enough cream to cover the affected and the surrounding skin areas and rub it in gently. Keep using the tioconazole cream even if the symptoms begin to clear up after a few days. Fungal infection may take a while for it to be cleared up. If you stop using the cream too soon, the symptoms may return, rendering the medicine ineffective.

It will be best if you keep taking it every day for several weeks or more until your provider says it is okay to stop. Tioconazole should be applied to the skin since it is both a cream and an ointment and it should not be taken orally.


When using tioconazole for vaginal yeast infection, it may interact with spermicide and other vaginal products including tampons and vaginal douche. You should inform your doctor if you use these before receiving the medicine.

The following treatments may increase the risks of yeast infections: antibiotics, corticosteroids, drugs that suppress immune systems like cyclosporine and methotrexate.

The effects of some drugs can change if you take other drugs simultaneously. It can lead to serious side effects or it may cause the tioconazole to not work effectively. Therefore, your doctor may have to either monitor your treatment closely or change how you take the medications.


It may contain certain inactive ingredients that can cause allergic reactions. Your provider should know if you suffer from the following diseases and ailments: diabetes, immune system disease such as HIV and AIDs, and frequent vaginal yeast infection where it occurs either more than three times in six months or four times in a year.

Tioconazole may weaken rubber birth control devices such as latex condoms, diaphragms, and cervical caps. It contains mineral oil or petrolatum that weakens the latex material of the contraceptive devices. You should also avoid using these devices when you are on the treatment and three days after its completion. As a result, they would not be effective in preventing unwanted pregnancy. Instead, use another form of birth control not made of latex during the time frame of the treatment until further notice.

If the symptoms last longer than seven days or if they have not been improved three days after the treatment begins, you should notify your physician. It may be a sign that you're dealing with a more serious condition.

If you apply tioconazole to your skin, do not apply the airtight dressing on top of the cream unless your doctor says you should do so. The example would be a kitchen plastic wrap. It may lead to skin irritation. In addition, you should avoid wearing clothes that fit too tightly on you and are made out of synthetic materials like nylon. That includes tight-fitting pantyhose and nylon underwear. This type of clothing does not allow air circulation of the skins it may lead to skin irritation or it may render tioconazole less effective. You should wear loose clothing that is made out of natural material during the treatment.

There will be times when tioconazole does not treat the skin conditions within a certain time frame after you start using it or if the conditions become worse. In that case, you need to contact your physician. If you are suffering from ringworm of your body or yeast infection of your skin, it should not take more than two weeks for the ailments to clear up. If you have ringworm of your foot, it should be eradicated fully during the treatment within four to six weeks.

Bad health habits can also inhibit the treatment of the infections. To ensure that they have been treated for good, it is very important that you practice good health hygiene. That includes drying yourself completely after bathing.

As for pregnant women, there is no evidence that shows tioconazole is harmful to unborn infants; however, providers should only recommend it for this patient group if the benefit outweighs the risks or if there is no alternative treatment for the fungal infections. There is also no proof that the medicine is harmful when a mother breastfeeds her infant. No traces of the medicine is found in the human milk. Despite this, providers should use caution when administering it to nursing patients.


Tioconazole must be stored in a closed container at room temperature. It should not be exposed to heat, moisture, and direct light. Do not freeze it and keep it away from children. Once the medicine expires, it must be discarded. When treating the vaginal yeast infection, do not warm the applicator before applying the ointment to the vagina.


Patients can administer tioconazole themselves without their doctors' assistance. In fact, some of the brands are available without prescription like Vagistat and Monistat. The list of the conditions explained in this guide is not guaranteed to be complete for it is possible tioconazole can treat additional ailments that are not on the list.

It is the same with the list of side effects. This list is not complete and it is possible you can suffer side effects other than the ones described above. When you are taking the medicine, it is important to monitor your body's reactions to it and note the effects that only occur after the treatment commences. You should then notify your provider of the side effects whether they're serious or not.

Finally, it is important that you note all the drugs and other treatments that you're taking currently and notify your provider before receiving tioconazole. Your provider wants to make sure there will be no serious adverse effects as a result of the drug's interactions with tioconazole.

Last Reviewed:
December 24, 2017
Last Updated:
April 05, 2018
Content Source: