Pulmonary arterial hypertension is a killer disease associated with the heart that may result in the right side of the heart failing to function. With the introduction of Treprostinil as a drug to treat PAH, the number of effects of the disease has reduced significantly. Treprostinil can be administered orally, a form of dosage which improves exercise easiness and safety measures of usage.
Treprostinil has a half-life of about two to four hours where the drug’s active agents go inactive and harmless to the body requiring expulsion. Despite the excretion means from the body being still unknown, the drug’s actions are direct vasodilation on reticence of platelet aggregation, systemic and pulmonary arterial vascular beds.
As such, patients having NYHA Class II-IV symptoms for pulmonary arterial hypertension can use Treprostinil to reduce these symptoms related to exercise. On the contrary, Treprostinil has adverse side effects which fade away after some time and as such patients can undertake their duties while the drug performs its functions.
With Treprostinil used by a wide range of the population, its adverse side effects still occur in many patients while some show fewer side effects that are not unfavorable. Other than side effects, a correct prescription from a professional doctor with proper supervision may result in less or no effects, hence the effectiveness of the drug guaranteed.
The drug gets administered in three different methods and the oral route comes with various side effects. Again, the drug may cause different side effects to different patients. That is, some side effects may be experienced by some patients while some may not experience any at all.
Although not all side effects get experienced, for adverse results, you may need to see your doctor immediately. Side effects may come in a form that many patients believe is ordinary, but it's advisable that you contact your doctor or a healthcare provider for consultation.
Below are some of the common side effects accompanied by symptoms that will arise on instances of an overdose.
With the above list of side effects, these effects should be reported immediately for assistance from your doctor. Not all the results may accompany Treprostinil administration, but any side effects experienced may fade away after some period of time.
Treprostinil, which is administered orally, can have a favorable action to the patient's body but with a correct prescription from a doctor. It's supplied in 5 extended-release quantity concentrations of 0.125mg, 0.25mg, 1mg, 2.5mg and 5mg, hence bottles having five different concentrations of drugs. Your doctor may prescribe Treprostinil drugs as per the side effects experienced, your health record history or recent treatments you have undertaken.
Treprostinil bottles and boxes are packed differently with each having different concentrations of ingredients. Unique ingredients to containers enable patients with different responses to the drug to be prescribed the needed dosages by their body reaction rates and the constant level of the disease.
Treprostinil is taken orally two or three times a day as prescribed by the doctor. It involves drugs, capsules or tablets with keen analysis from a doctor to determine the drug type to administer. During prescription, some considerations are contemplated. These involve Treprostinil should be taken with food, the tablets should be swallowed as a whole and any others your doctor can describe before prescription.
Also, your doctor should have an ability to undertake titration of the drugs to facilitate dose adjustments. It establishes a starting point for patients with mild hepatic complications and also for those using other medicines to avoid cases of drug interactions.
The dosage of Treprostinil is usually done with methods of calculations to determine the actual amount used for any patient. That is, in case of any drug adjustment or for those who require little dosages, the amount of the drug can be determined by use of formulas generated by a specialist or through laboratory tests involving titrations. The equations are of the different population depending on the type of condition hindering the administration of the actual dosage.
Treprostinil should be taken after meals, and patients are typically advised to choose foods that adequately contribute to the increase of blood in the body, such as fruits. Children can be prescribed Treprostinil, but research shows that they are rarely susceptible to pulmonary arterial hypertension as they are still growing and usually indulge in a lot of activities during their childhood period.
It is very crucial to undertake regular checkups to ensure that the medicine is working appropriately, as well an assessment of how the body is responding. Blood tests and general body analysis may be done to ensure that no internal or unseen damages are being done by the drug. That said, make sure that you attend all your scheduled doctor's appointments to facilitate proper functioning of the drug and a smooth healing process.
Drugs interact with each other, and if a reaction occurs in the body, these drugs may end up ineffective or result in toxins in the body. As such, patients going for Treprostinil administration need to have a list of all the medications they are using presently and the frequency of dosage. Again, they should provide a doctor with their medical history. This process will make the doctor aware of the means of administration of the drug, make adjustments if any, prescribe differently or cancel the prescription of Treprostinil.
There are some drugs that patients have reported to have caused significant interactions with Treprostinil. If any patient is using these drugs, then do not use Treprostinil before consulting your doctor, especially medicine used in curing blood problems.
More so, patients are advised to report any interactions that may occur while using Treprostinil. Other than drug interferences, they are also encouraged to report adverse and unlikely effects that they may experience - the doctor may alter the prescription or use other means of administration.
With many patients buying drugs randomly in pharmacies, some drugs not mentioned above may also invert the functioning of Treprostinil, hence making it ineffective. As such, any drug introduced while still under the prescription of Treprostinil needs to be recommended by your doctor. These random drug administrations may also result in harmful reactions with the medicine and may sometimes cause additional damage to the body cells; pulmonary arterial hypertension included.
Discuss medical history, drugs on prescription by the patient and any allergic reactions with your doctor - further illnesses have to be included in the consultation as well. That involves telling your doctor about other illness conditions such as persistent complications or drug addictions, for instance alcohol that may affect Treprostinil functions. Some of the conditions that may cause Treprostinil to be extremely dangerous in your body include:
Patients should follow the doctor’s instructions strictly without failure. Following the prescriptions provided and adhering to the doctor's instructions will enable the medicine to kick in and be effective. Avoid instant drug withdrawal or an immediate reduction or increase in the drug dosage. Such doings will increase the symptoms of the disease, hence worsening your condition.
Patients suffering from Hepatic or Renal deficiency have a higher rate of exposure to systematic concentration than other normal patients, hence the titration of Treprostinil solution slowly will enable them to be safer. On that note, patients suffering from diverticulosis should also be warned that using this drug is risky. It is because Treprostinil's capsule shell does not dissolve, so it may camp in the diverticulum leading to more complicated conditions.
Some drugs such as gemfibrozil, an enzyme inhibitor, may increase the exposure rate to Treprostinil, while other drugs such as rifampin, an enzyme inducer, may decrease the functioning of Treprostinil, altering the effectiveness of the drug.
Treprostinil has to be used in some specific individuals, while others such as pregnant women, need to acquire advice from their doctors to find an appropriate method of administration and the frequency of drug administration. During the labor or delivery process of expectant mothers, Treprostinil has been found to have no effects on either the child or the mother, but still seek medical advice from your doctor.
Elderly and pediatric persons should undergo Treprostinil medication with sufficient precaution as the effects to these populations has not yet been proven. Hence, seeing your doctor for blood assessment and clarification of use is recommended.
Some medical analysis may be required before administration. It involves pregnant women and lactating mothers among other special occasions. If you are already pregnant or are planning to get pregnant, consult your doctor before taking these drugs. For breastfeeding mothers, the drugs have not yet proven to get into breast milk but ask your doctor before taking any Treprostinil medicine.
Other than medical history, some patients may experience severe allergic reactions that have not yet been noticed by your doctor during drug administration. When such happens, stop taking the drug immediately and seek medical attention from your doctor or healthcare personnel. Some individuals may have some side effects also, not mentioned here, as such, immediate medical care is required.
Treprostinil is found to increase the possibilities of random bleeding, especially for those patients who take blood thinners. For such circumstances, notify your doctor if you are taking blood thinners, for example warfarin.
Treprostinil should be stored at up to 25°C (77°F) - a range of 15° C to 25° C (59°F to 77° F). Also as indicated by the manufacturers, the medicine should be stored in a cool, dry place away from direct sunlight and out of reach of children.
With its ability to treat pulmonary arterial hypertension, the drug has ingredients which will get inactive after some period. When stored for a long time, the drug may reach its expiration date and once achieved, seek medical advice for a new prescription. As such, one bottle of Treprostinil should be used within 30 days.
As Treprostinil is a significant medicine to aid individuals suffering from pulmonary arterial hypertension, the drug has some side effects which are adverse. Patients with any medical history or have a prescription for other medicines that may interact with Treprostinil need to seek immediate medical advice before using it.
Treprostinil has a shorter half-life hence its effectiveness being experienced almost immediately after taking them. Despite the excretion method from the body not yet being known, its treatment on PAH has positive reports from different patients.
Treprostinil has a simple method of oral administration. When correctly administered and frequency of dosage done, Treprostinil can offer relief from adverse side effects though a few will be experienced by the patients.
Treprostinil comes with different formulas, hence it is a great fit for any population other than those patients with complicated problems. With equations and titration techniques, a patient may be derived a prescription amount generated from scientifically proved formulas. The drug is then considered safe for use by any patient.