Triptorelin (Intramuscular)

Triptorelin is a hormone similar to one regularly released in the brain, which is used to treat advanced prostate cancer in men. Triptorelin works by decreasing levels of certain hormones in the body


Triptorelin is used to treat advanced prostate cancer in men, and is similar to a hormone that is naturally produced in the hypothalamus gland of the brain. It is a gonadotropin releasing hormone (GnRH) agonist, which is a medication that decreases the amount of certain hormones in the body. When given regularly, triptorelin decreases testosterone levels.

Triptorelin injections are also administered as treatment for a condition called central precocious puberty (CPP), which can cause children to enter puberty much earlier than anticipated.

This medicine comes as an extended-release suspension to be injected by your doctor or nurse into a muscle of either buttock. This medicine is to be given only by or under the supervision of a doctor. Your dosage is based on your specific medical condition and the therapy prescribed.

Conditions Treated

Type of Medicine

  • Hormone therapy
  • Gonadotropin-releasing hormone (GnRH) agonist

Side Effects

When taking a prescribed medicine, some side effects may emerge alongside the intended effects of the medicine. Although these unwanted effects may not occur, if they occur they require medical attention.

Contact your doctor or nurse immediately if any of the following side effects occur while taking triptorelin:

Less Common:

  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • burning while urinating
  • chest pain
  • cough producing mucus
  • decrease in urine volume or frequency or urination
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • difficulty in passing urine
  • dizziness
  • dry mouth
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • lower back or side pain
  • nausea
  • nervousness
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • slow or fast heartbeat
  • stomachache
  • sweating
  • tightness in chest
  • tingling of the hands or feet
  • troubled breathing
  • troubled breathing with exertion
  • unusual weight loss
  • unusual weight gain
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence not known:

  • Anxiety
  • changes in skin color
  • changes in vision
  • chest discomfort
  • cold, clammy, or pale skin
  • confusion
  • dizziness or lightheadedness
  • fainting
  • inability to speak
  • irregular heartbeats
  • numbness or tingling in the face, arms, or legs
  • pain or discomfort in the arms, jaw, back or neck
  • pain, redness or swelling in the arm or leg
  • seizures
  • severe or sudden headache
  • slow heart rate
  • slurred speech
  • sudden shortness of breath or troubled breathing
  • sudden and severe weakness in the arm or leg on one side of the body
  • temporary blindness
  • tenderness
  • trouble speaking, thinking or walking

Some side effects of triptorelin may occur that do not necessarily require medical attention. These side effects may disappear as your body adjusts to the medicine. Also, your doctor may be able to inform you of ways to prevent or reduce some of these side effects. Check with your doctor or nurse if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common:

  • Bone pain
  • Chills
  • decrease in testicle size
  • decreased interest in sexual intercourse
  • diarrhea
  • feeling of warmth or redness of the face, neck, arms, and occasionally upper chest
  • fever
  • general feeling or discomfort or illness
  • inability to have or keep an erection
  • joint pain
  • leg pain
  • loss in sexual ability, desire, drive or performance
  • loss of appetite
  • muscle aches and pains
  • runny nose
  • shivering
  • sore throat
  • sudden sweating
  • trouble sleeping

Less Common:

  • Acid or sour stomach
  • back pain
  • belching
  • body aches or pain
  • Breast pain
  • burning, dry or itchy eyes
  • congestion
  • crying
  • decrease in personalization
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • discharge or excessive tearing
  • dysphoria
  • euphoria
  • eye pain
  • heartburn
  • hoarseness
  • indigestion
  • injection site pain
  • itching or rash
  • lack or loss of strength
  • leg cramps
  • muscle cramping or stiffness
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • stomach discomfort, pain or upset stomach
  • swelling of the breasts or breast soreness
  • swollen joints
  • tender, swollen glands in the neck
  • trouble swallowing
  • voice changes

Ask your doctor or nurse for more information about possible side effects. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your doctor or nurse. You may also report side effects to the FDA by filling out an online form on the FDA's website or at 1-800-FDA-1088.


Triptorelin is administered by your doctor or nurse. This medicine is given as a shot into your muscle in either buttock.
This medicine needs to be administered on a fixed schedule. Make sure to keep all of your appointments.

Triptorelin may cause an increase in certain hormones in the first few weeks after the first injection. Your doctor will monitor you carefully for any new or worsening symptoms during this time.

For Prostate Cancer:

Adults and children 12 years of age and older- 3.75 mg intramuscularly every 4 weeks, 11.25 mg intramuscularly every 12 weeks, or 22.5 mg intramuscularly every 24 weeks.

For central precocious puberty:

Children younger than 12 years of age- an injection of 22.5 mg is usually given every 24 weeks.


Some certain medicines may interact with triptorelin in an adverse or undesired way. It is important for you to keep a list of all of the nonprescription (over-the-counter) and prescription medicines you are taking, as well as any minerals, vitamins, or other dietary supplements. Be sure to also include any of the following: amiodarone (Nexterone, Pacerone), reserpine, carbamazepine (Tegretol, Teril), bupropion (Aplenzin, Wellbutrin, Zyban), methyldopa (in Aldoril), metoclopramide (Reglan), or selective serotonin reuptake inhibitors (or SSRIs) such as fluoxetine (Prozac), sertraline (Zoloft), as well as paroxetine (Paxil). You should bring the list of medicines with you when you visit a doctor or are admitted to the hospital. Keep this list with you in case of emergencies.

If you are using any of these medicines prior to using triptorelin, you may not be able to use triptorelin or you may need dosage adjustments or special tests during treatment. Discuss the interactions with the previously mentioned drugs and possible dosage changes with your doctor or nurse.

Your doctor or nurse may be aware of medicines that interact with triptorelin and may already be monitoring you for them. Do not alter the dosage of any medicine in any way before checking with your doctor or nurse first. Ask your doctor or nurse for more information on drugs that may possibly interact with triptorelin.

Do not take any other medicines without contacting your doctor about them first. This includes prescription or nonprescription medicines as well as herbal, vitamin, or dietary supplements.

Certain medicines should not be used at or around the time of eating food or certain types of food as some interactions may occur. Additionally, the use of alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your doctor the use of triptorelin with food, alcohol or tobacco.


Tell your doctor before taking triptorelin if you are allergic to triptorelin, goserelin (Zoladex), leuprolide (Eligard, Lupron), histrelin (Supprelin LA, Vantas), nafarelin (Synarel) or if you have any other allergies to other medicines. This product may contain inactive ingredients that could possibly cause allergic reactions or other problems.

Triptorelin should not be used if you have or have had certain medical conditions. These previous conditions could possibly complicate the treatment and success of this medicine. Consult your doctor before using this medicine if you have ever had diabetes, cancer that has spread to the spine, a low level of potassium, a urinary obstruction, calcium, or magnesium in your blood, heart failure, a heart attack, a mental illness, a stroke, a seizure or epilepsy, or other brain problems, a brain tumor, or heart, kidney or liver disease. Tell your doctor if you or anyone in your family has ever had a long QT Syndrome (a condition that increases the risk of developing an irregular heartbeat, leading to fainting or sudden death).

This medicine may cause a serious allergic reaction called anaphylaxis. This can be life-threatening and requires immediate medical attention. If you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive the medicine, call your doctor immediately.

If you are pregnant, triptorelin should not be used. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking triptorelin, call your doctor immediately.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness while using triptorelin, until you are sure you can perform such activities safely.

In case of emergency, or if the victim has collapsed or is no longer breathing, call the local emergency services at 911.


It is important that your progress is checked by your doctor at regular visits. While you are taking triptorelin, blood tests should be done every few months to make sure that the medicine is working properly. Blood and urine tests may be needed for unwanted effects.

Using triptorelin may raise some hormone levels in your body during the first weeks of taking the medicine. This medicine may also lower some hormone levels in your body. It may cause some effects like a change in breast size, breast tenderness or soreness, testicle changes in men, change in sex ability in men, sweating or hot flashes.

Lowering male hormones may also raise the chance of an irregular heartbeat (prolonged QT interval). Symptoms may get worse before getting better, tell your doctor if you have any new signs or if your symptom signs are worse for more than a few weeks after starting treatment.

The chance of very bad and possibly deadly problems may be raised in people who have growths on or near the spine or spinal cord or bladder blockage. Consult with your doctor or nurse about the complications that may arise from these issues.

Triptorelin can also lead to behavior and mood changes in children. This includes acting aggressively, crying, suffering from depression, experiencing emotional ups and downs, restlessness, and feeling angry and irritable. Call your doctor immediately if any new or worse behavior or mood changes occur.

Consult with your doctor if you have high blood sugar (diabetes) before taking triptorelin, as this medicine may raise blood sugar.


Store the medicine in the original, closed container at room temperature, away from excess heat, moisture and direct light. Keep from freezing. Outdated medicine should not be kept longer than needed or intended.

Keep out of reach of children.

Administer immediately after reconstitution.


Triptorelin is a hormone similar to one that naturally occurs in the hypothalamus gland of the brain, and is administered to patients to treat prostate cancer. Triptorelin is also used as a treatment central precocious puberty (CPP, a condition where children begin entering puberty too soon, which results in faster than normal bone growth and development of sexual characteristics too quickly). When given on a regular basis to men, triptorelin will result in the decrease of testosterone levels.

Make sure to notify your doctor or your nurse of your medical history before considering using triptorelin. Prior medical conditions and existing conditions could complicate or worsen during treatment with triptorelin. Additionally, notify your doctor of any and all medications, vitamins and supplements you are currently taking before considering using triptorelin. Your doctor may alter your treatment accordingly.

Never miss appointments with your doctor where you would be receiving a dose of triptorelin. This medicine affects each patient differently, and modifications to treatment may result in more or worsened side effects. Missing a dose could possible jeopardize the treatment schedule and affect the severity of side effects, as well as treatment progress.

Check with your doctor regularly concerning side effects, especially if they worsen or change in some way. Report any side effects that may arise that were not listed above to your doctor and the FDA as soon as they occur.

Last Reviewed:
December 26, 2017
Last Updated:
April 05, 2018
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