Monoclonal Gammopathy of Undetermined Significance (MGUS)

What is Monoclonal Gammopathy of Undetermined Significance?

Monoclonal Gammopathy of Undetermined Significance (MGUS) is a benign (non-cancerous) condition where large amounts of particular antibody are produced in the system. This antibody is referred to as a paraprotein or M-protein.

What are the Symptoms of Monoclonal Gammopathy of Undetermined Significance?

There are no known symptoms of Monoclonal Gammopathy of Undetermined Significance (MGUS). It can be diagnosed through urine and blood test screening. A person may need to have other tests in order to rule out more serious medical conditions. Additional testing could include x-rays, CT-Scans or review of a bone marrow sample.

How is Monoclonal Gammopathy of Undetermined Significance Treated?

Since Monoclonal Gammopathy of Undetermined Significance (MGUS) shows no symptoms, treatment is not necessary but the diagnosed patient must be monitored regularly. There are a small percentage of people with MGUS who can develop a more serious plasma cell disease. In addition, MGUS can be connected with other diseases such as osteoporosis.

A person will have a blood test to check M-Protein levels every few months within the first year. The healthcare provider will monitor the M-protein patterns. These are monitored to determine whether they stay are on the rise, or roughly the same with each laboratory result. If the M-protein levels remain steady and nothing else becomes a concern, appointments and testing times will be further apart as time passes. If the m-protein levels are on the rise, repeat testing may be required along with testing for other possible causes.