Monoclonal Gammopathy of Undetermined Significance (MGUS) is a benign (non-cancerous) condition where large amounts of particular antibody are produced in the system. This antibody is referred to as a paraprotein or M-protein.
There are no known symptoms of Monoclonal Gammopathy of Undetermined Significance (MGUS). It can be diagnosed through urine and blood test screening. A person may need to have other tests in order to rule out more serious medical conditions. Additional testing could include x-rays, CT-Scans or review of a bone marrow sample.
Since Monoclonal Gammopathy of Undetermined Significance (MGUS) shows no symptoms, treatment is not necessary but the diagnosed patient must be monitored regularly. There are a small percentage of people with MGUS who can develop a more serious plasma cell disease. In addition, MGUS can be connected with other diseases such as osteoporosis.
A person will have a blood test to check M-Protein levels every few months within the first year. The healthcare provider will monitor the M-protein patterns. These are monitored to determine whether they stay are on the rise, or roughly the same with each laboratory result. If the M-protein levels remain steady and nothing else becomes a concern, appointments and testing times will be further apart as time passes. If the m-protein levels are on the rise, repeat testing may be required along with testing for other possible causes.